Differential patterning of ventral midline cells by axial mesoderm is regulated by BMP7 and chordin

Ventral midline cells in the neural tube have distinct properties at different rostrocaudal levels, apparently in response to differential signalling by axial mesoderm. Floor plate cells are induced by sonic hedgehog (SHH) secreted from the notochord whereas ventral midline cells of the rostral dien...

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Bibliographic Details
Published in:	Development (Cambridge) Vol. 126; no. 2; pp. 397 - 408
Main Authors:	Dale, K, Sattar, N, Heemskerk, J, Clarke, J D, Placzek, M, Dodd, J
Format:	Journal Article
Language:	English
Published:	England The Company of Biologists Limited 01-01-1999
Subjects:	Animals Body Patterning Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Movement Chick Embryo Embryo, Nonmammalian - cytology Embryonic Development Gene Expression Regulation, Developmental Glycoproteins - genetics Glycoproteins - metabolism Hedgehog Proteins Immunohistochemistry In Situ Hybridization Intercellular Signaling Peptides and Proteins Mesoderm - metabolism Microscopy, Electron, Scanning Proteins - genetics RNA, Messenger - analysis Signal Transduction - physiology Spinal Cord - growth & development Trans-Activators Transforming Growth Factor beta
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