Glutathione depletion: its effects on other antioxidant systems and hepatocellular damage

1. The mechanisms of the liver damage produced by three glutathione (GSH)-depleting agents, bromobenzene, allyl alcohol and diethyl maleate, were investigated. 2. With each toxin liver necrosis was accompanied by lipid peroxidation that developed only after severe depletion of GSH. 3. Changes in ant...

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Bibliographic Details

Published in:	Xenobiotica Vol. 21; no. 8; p. 1067
Main Authors:	Comporti, M, Maellaro, E, Del Bello, B, Casini, A F
Format:	Journal Article
Language:	English
Published:	England 1991
Subjects:	Animals Antioxidants - pharmacology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Glutathione - antagonists & inhibitors Glutathione - physiology Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism
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