Targeted Overexpression of Tissue Inhibitor of Matrix Metalloproteinase-4 Modifies Post–Myocardial Infarction Remodeling in Mice

RATIONALE:Myocardial infarction (MI) causes an imbalance between matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases (TIMPs) and is associated with adverse left ventricular (LV) remodeling. A uniform reduction in TIMP-4 post-MI has been observed. OBJECTIVE:To examine post-MI...

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Bibliographic Details
Published in:	Circulation research Vol. 114; no. 9; pp. 1435 - 1445
Main Authors:	Zavadzkas, Juozas A, Stroud, Robert E, Bouges, Shenikqua, Mukherjee, Rupak, Jones, Jeffrey R, Patel, Risha K, McDermott, Paul J, Spinale, Francis G
Format:	Journal Article
Language:	English
Published:	United States American Heart Association, Inc 25-04-2014
Subjects:	Adenoviridae - genetics Animals Apoptosis Cytokines - genetics Cytokines - metabolism Disease Models, Animal Fibrillar Collagens - genetics Fibrillar Collagens - metabolism Gene Expression Regulation Gene Targeting Gene Transfer Techniques Genetic Vectors Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mice Mice, Transgenic Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Recombinant Fusion Proteins - metabolism Recovery of Function RNA, Messenger - metabolism Stroke Volume Time Factors Tissue Inhibitor of Metalloproteinase-4 Tissue Inhibitor of Metalloproteinases - genetics Tissue Inhibitor of Metalloproteinases - metabolism Ventricular Function, Left Ventricular Remodeling tissue inhibitor of metalloproteinases extracellular matrix myocardial infarction ventricular function
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