Induction of DNA-strand breaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: association with 8-oxo-2-deoxyguanosine formation and inter-individual variability

Hexavalent chromium [Cr(VI)] is a genotoxic carcinogen for which inhalation is a major potential route of exposure in occupational settings. In the present study, the ability of sodium dichromate to cause DNA strand breaks in three populations of cells, human whole blood cells, isolated human periph...

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Bibliographic Details
Published in:	Mutagenesis Vol. 16; no. 6; pp. 467 - 474
Main Authors:	Hodges, N.J., Ádám, B., Lee, A.J., Cross, H.J., Chipman, J.K.
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Oxford Oxford University Press 01-11-2001 Oxford Publishing Limited (England)
Subjects:	8-oxo-2-deoxyguanosine Adolescent Adult Biological and medical sciences Cells, Cultured Chromates - toxicity Chromium - toxicity Comet Assay - statistics & numerical data Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA - blood DNA Damage - drug effects DNA, Neoplasm - metabolism Female Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Lung Neoplasms - genetics Lung Neoplasms - metabolism Lymphocytes - drug effects Lymphocytes - metabolism Male Middle Aged Molecular and cellular biology Oxidative Stress - drug effects Oxidative Stress - genetics Tumor Cells, Cultured
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