Regional distribution of wall thickness and failure properties of human abdominal aortic aneurysm

• Published in: Journal of biomechanics Vol. 39; no. 16; pp. 3010 - 3016
• Main Authors: Raghavan, Madhavan L., Kratzberg, Jarin, Castro de Tolosa, Erasmo Magalhães, Hanaoka, Mauro M., Walker, Patricia, da Silva, Erasmo Simão
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01-01-2006; Elsevier Limited
• Subjects: Abdominal aortic aneurysm; Aged; Aged, 80 and over; Aneurysms; Aorta, Abdominal - physiopathology; Aortic Aneurysm, Abdominal - physiopathology; Aortic Rupture - physiopathology; Biomechanics; Blood clots; Elasticity; Failure strength; Female; Humans; Male; Measurement techniques; Middle Aged; Models, Cardiovascular; Stress, Mechanical; Tensile Strength; Wall thickness; Brazil; Biomechanics; Wall thickness; Failure strength; Abdominal aortic aneurysm
• ISSN: 0021-9290; 1873-2380
• DOI: 10.1016/j.jbiomech.2005.10.021

The regional distribution of wall thickness and failure properties in human abdominal aortic aneurysm (AAA) was explored. Three unruptured and one ruptured AAA were harvested as a whole during necropsy. Thickness was measured at about every 1.5
cm
2 wall surface area for an average of 100 measurement sites per AAA. Multiple longitudinally oriented rectangular specimen strips were cut at various locations from each AAA for a total of 48 strips. The strips were subjected to uniaxial extension until failure. Wall thickness varied regionally and between AAA from as low as 0.23
mm at a rupture site to 4.26
mm at a calcified site (median=1.48
mm). Wall thickness was slightly lower in the posterior and right regions. The failure tension (ultimate) of specimen strips varied regionally and between AAA from 5.5
N/cm close to a blister site in the ruptured AAA to 42.3
N/cm at the undilated neck of a 4
cm diameter unruptured AAA (median=14.8
N/cm). Failure stress (ultimate) varied from 33.6 to 235.1
N/cm
2 (median=126.6
N/cm
2). There was no perceptible pattern in failure properties along the circumference. Failure tension of specimen strips at or close to blisters was mostly low. The rupture site in the ruptured aneurysm had the lowest recorded wall thickness of 0.23
mm with only slightly higher readings within a 1
cm radius. The failure tension of the specimen strip close to the rupture site was low (11.1 N/cm) compared to its neighborhood in the ruptured aneurysm.