Biological and Serological Characterization of Radiation Leukemia Virus

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 73; no. 12; pp. 4675 - 4679
• Main Authors: Decléve, Alain, Lieberman, Miriam, Ihle, James N., Kaplan, Henry S.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01-12-1976; National Acad Sciences
• Subjects: Animals; Antigens, Viral - analysis; Antiserum; Cell lines; Cross Reactions; Embryos; Female; Fibroblasts; Fibroblasts - microbiology; Glycoproteins; Glycoproteins - immunology; Infections; Leukemia Virus, Murine - classification; Leukemia Virus, Murine - immunology; Leukemia Virus, Murine - radiation effects; Lymphoma; Male; Mice; Mice, Inbred Strains; Radiation leukemia virus; Serotyping; Species Specificity; Thymus Gland - microbiology; Viral Proteins - immunology; Virus Replication; Viruses
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.73.12.4675

Radiation leukemia virus, isolated from radiation-induced lymphomas in C57BL/Ka mice and propagated in that strain, is thymotropic and leukemogenic in vivo but replicates poorly, if at all, in mouse and mink fibroblast cultures in vitro. Comparative studies indicate that this naturally occurring virus is distinct from the previously recognized classes of endogenous murine ecotropic and xenotropic C-type viruses which are capable of replication on fibroblasts (fibrotropic) but are neither thymotropic nor leukemogenic. These studies also demonstrate that a differentiation-specific restriction system governing the replication of the murine ecotropic C-type viruses operates in addition to the previously defined Fv-1 and SRV gene restriction systems.