Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets

A major task for the immune system is to secure powerful immune reactions while preserving self-tolerance. This process is particularly challenging for NK cells, for which tolerizing inhibitory receptors for self-MHC class I is both cross-reactive and expressed in an overlapping fashion between NK c...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 188; no. 5; pp. 2218 - 2226
Main Authors:	Brodin, Petter, Lakshmikanth, Tadepally, Kärre, Klas, Höglund, Petter
Format:	Journal Article
Language:	English
Published:	United States 01-03-2012
Subjects:	Animals Apoptosis - genetics Apoptosis - immunology Cell Proliferation Cells, Cultured Dose-Response Relationship, Immunologic Female H-2 Antigens - biosynthesis H-2 Antigens - genetics Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Subsets - cytology Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Medicin och hälsovetenskap Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic NK Cell Lectin-Like Receptor Subfamily A - biosynthesis NK Cell Lectin-Like Receptor Subfamily A - deficiency NK Cell Lectin-Like Receptor Subfamily A - immunology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!