Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism

Follistatin (FST)-type proteins are important antagonists of some members of the large TGF-β family of cytokines. These include myostatin, an important negative regulator of muscle growth, and the closely related activin A, which is involved in many physiological functions, including maintenance of...

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Bibliographic Details
Published in:	Molecular endocrinology (Baltimore, Md.) Vol. 26; no. 7; pp. 1167 - 1178
Main Authors:	Cash, Jennifer N, Angerman, Elizabeth B, Keutmann, Henry T, Thompson, Thomas B
Format:	Journal Article
Language:	English
Published:	United States Endocrine Society 01-07-2012 Oxford University Press
Subjects:	Activins - antagonists & inhibitors Activins - chemistry Animals Cell Line Follistatin - chemistry Follistatin - metabolism Follistatin-Related Proteins - chemistry Follistatin-Related Proteins - genetics Follistatin-Related Proteins - metabolism HEK293 Cells Humans Mice Myostatin - antagonists & inhibitors Myostatin - chemistry Original Research Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary
Online Access:	Get full text
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