CYP4A metabolites of arachidonic acid and VEGF are mediators of skeletal muscle angiogenesis

Vascular endothelial growth factor (VEGF) has been implicated in angiogenesis induced by electrical stimulation in skeletal muscle. Less is known about the role of arachidonic acid metabolites in the control of growth of blood vessels in vivo. The present study examined the role of 20-hydroxyeicosat...

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Bibliographic Details
Published in:	American journal of physiology. Heart and circulatory physiology Vol. 284; no. 5; p. H1528
Main Authors:	Amaral, Sandra L, Maier, Kristopher G, Schippers, Daniela N, Roman, Richard J, Greene, Andrew S
Format:	Journal Article
Language:	English
Published:	United States 01-05-2003
Subjects:	Amidines - pharmacology Animals Antibodies - pharmacology Arachidonic Acid - metabolism Cytochrome P-450 CYP4A Cytochrome P-450 Enzyme System - metabolism Electric Stimulation Endothelial Growth Factors - immunology Endothelial Growth Factors - metabolism Enzyme Inhibitors - pharmacology Hydroxyeicosatetraenoic Acids - metabolism Intercellular Signaling Peptides and Proteins - immunology Intercellular Signaling Peptides and Proteins - metabolism Lymphokines - immunology Lymphokines - metabolism Male Mixed Function Oxygenases - metabolism Muscle, Skeletal - blood supply Neovascularization, Physiologic - physiology Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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