Evaluation of photodynamic therapy on fibroblast viability and cytokine production

• Published in: Photodiagnosis and photodynamic therapy Vol. 13; pp. 97 - 100
• Main Authors: Gomes-Filho, João Eduardo, Sivieri-Araujo, Gustavo, Sipert, Carla Renata, da Silva Santos, Ludmilla Mota, de Azevedo Queiroz, Índia Olinta, Men Martins, Christine, do Carmo Maia, Nayara Kívilla, Cintra, Luciano Tavares Angelo, Dezan-Junior, Eloi, Bagnato, Vanderlei Salvador, Chaves-Neto, Antônio Hernandes, de Oliveira, Sandra Helena Penha
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-03-2016
• Subjects: Animals; Cell Line; Cell Survival - drug effects; Cell Survival - physiology; Curcumin - administration & dosage; Cytokine; Cytokines - metabolism; Cytotoxicity; Endodontic treatment; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Hematology, Oncology and Palliative Medicine; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Internal Medicine; Mice; Photochemotherapy - methods; Photodynamic therapy; Photosensitizing Agents - administration & dosage; Root canal irrigants; Endodontic treatment; Root canal irrigants; Cytotoxicity; Photodynamic therapy; Cytokine
• ISSN: 1572-1000; 1873-1597
• DOI: 10.1016/j.pdpdt.2016.01.007

Highlights • This study evaluated the effects of photodynamic therapy with curcumin compared to 5% sodium hypochlorite and saline solution. • The effects on fibroblasts viability and on IL-1β and IL-6 cytokine releasing were evaluated. • The photodynamic therapy, saline solution and control presented low cytotoxic effect, while 5% NaOCl was more cytotoxic. • All materials similarly expressed IL-1β and IL-6.