Glutathione pegylated liposomal methylprednisolone administration after the early phase of status epilepticus did not modify epileptogenesis in the rat

• Published in: Epilepsy research Vol. 108; no. 3; pp. 396 - 404
• Main Authors: Holtman, Linda, van Vliet, Erwin A, Appeldoorn, Chantal, Gaillard, Pieter J, de Boer, Marco, Dorland, Rick, Wadman, Wytse J, Gorter, Jan A
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01-03-2014; Elsevier
• Subjects: Albumins; Animals; Anti-Inflammatory Agents - administration & dosage; Biological and medical sciences; Brain inflammation; CD11b Antigen - metabolism; Disease Models, Animal; Drug Delivery Systems; Electrodes, Implanted - adverse effects; Glutathione - administration & dosage; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampus - pathology; Hippocampus - physiopathology; Liposomes; Male; Medical sciences; Methylprednisolone; Methylprednisolone - administration & dosage; Methylprednisolone - blood; Microglia - drug effects; Microglia - metabolism; Nervous system (semeiology, syndromes); Neurology; Phospholipids - administration & dosage; Phosphopyruvate Hydratase - metabolism; Pulse treatment; Rats; Rats, Sprague-Dawley; Status Epilepticus - drug therapy; Status Epilepticus - etiology; Temporal lobe epilepsy; Time Factors; Temporal lobe epilepsy; Liposomes; Methylprednisolone; Brain inflammation; Pulse treatment; Rat; Complex partial epilepsy; Encephalon; Subintrant crisis; Pegylated form; Status epilepticus; Glutathione; Corticosteroid; Nervous system diseases; Steroid hormone; Early phase; Rodentia; Liposome; Inflammation; Cerebral disorder; Vertebrata; Mammalia; Treatment; Animal; Central nervous system disease; Immunosuppressive agent
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2014.01.010

Highlights • Liposome nanotechnology is used to enhance brain delivery of methylprednisolone. • Methylprednisolone did not affect status epilepticus induced epileptogenesis. • Methylprednisolone did not reduce status epilepticus induced microgliosis.