The impact of operative time and hypothermia in acute burn surgery

• Published in: Burns Vol. 43; no. 8; pp. 1673 - 1681
• Main Authors: Ziolkowski, N., Rogers, A.D., Xiong, W., Hong, B., Patel, S., Trull, B., Jeschke, M.G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-12-2017
• Subjects: Acute Disease; Adult; Aged; Burns - complications; Burns - surgery; Female; Humans; Hypothermia - epidemiology; Hypothermia - etiology; Incidence; Male; Middle Aged; Operative Time; Perioperative Period - statistics & numerical data; Poisson Distribution; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Risk Factors; Surgical Wound Infection - epidemiology; Young Adult
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/j.burns.2017.10.001

•Millions of burn injuries undergo operative treatment per year.•Limited evidence is available to guide perioperative practice.•Patients who undergo prolonged surgery are prone to hypothermia.•Perioperative hypothermia predisposes patients with major burn injury to both infectious and non-infectious complications.
Prolonged operative time and intraoperative hypothermia are known to have deleterious effects on surgical outcomes. Although millions of burn injuries undergo operative treatment globally every year, there remains a paucity of evidence to guide perioperative practice in burn surgery. This study evaluated associations between hypothermia and operative time on post-operative complications in acute burn surgery.
A historical cohort study from January 1, 2006 to October 31, 2015 was completed at an American Burn Association verified burn centre. 1111 consecutive patients undergoing acute burn surgery were included, and 2171 surgeries were analyzed.
Primary outcomes included post-operative complications, defined a priori as either infectious or noninfectious. Statistical analysis was undertaken using a modified Poisson model for relative risk, adjusted for total body surface area, inhalation injury, co-morbidities, substance abuse, and age.
The mean operative time was 4.4h (SD 3.7–4.7h; range 0.58–11h), and 18.6% of patients became hypothermic intra-operatively. Operative time was independently associated with the incidence of hypothermia (p<0.05), and both infectious (RR1.5; 1.2–1.9, p<0.0004) and non-infectious complications (RR2.3; 1.3–4.1, p<0.0066). In patients with major burns (TBSA≥20%), hypothermia predisposed to infectious (RR1.3; 1.1–1.5, p<0.0017) and non-infectious complications (RR1.7; 1.2–2.5; p<0.0049). Risk stratification revealed that hypothermic patients with major burns undergoing prolonged surgery had an increased risk of both infectious (RR1.4; 1.1–1.7, p<0.0068) and non-infectious complications (RR1.8; 1.1–3.0, p<0.0132) when compared with those without these risk factors.
Patients who undergo prolonged surgeries and become hypothermic are more likely to develop complications. We therefore advocate for diligent adherence to strategies to prevent hypothermia and recommend limiting operative time in clinical circumstances where intraoperative measures are unlikely to adequately prevent hypothermia.