Double lung transplantation is better than single lung transplantation for end-stage chronic obstructive pulmonary disease: a meta-analysis

• Published in: Journal of cardiothoracic surgery Vol. 19; no. 1; pp. 162 - 13
• Main Authors: Fang, Yu-Chi, Cheng, Wen-Hsin, Lu, Hung-I, Wang, Yi-Shi, Chuang, Kai-Hao, Lai, Hsing-Hua, Chen, Yu, Chen, Li-Chun, Tsai, Meng-Yun, Chang, Yu-Ping, Huang, Kuo-Tung, Lo, Chien-Ming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30-03-2024; BioMed Central; BMC
• Subjects: Analysis; Care and treatment; Chronic obstructive; Chronic obstructive pulmonary disease; Lung diseases; Lung transplantation; Lung transplants; Lungs; Meta-analysis; Mortality; Patients; Proportional hazards models; Pulmonary disease; Quality of life; Ratios; Registries; Surgery; Survival; Transplantation; Transplantation of organs, tissues, etc; Pulmonary disease; Chronic obstructive; Lung transplantation; Registries; Proportional hazards models; Survival; Meta-analysis
• ISSN: 1749-8090; 1749-8090
• DOI: 10.1186/s13019-024-02654-6

Lung transplantation is one of the most common treatment options for patients with end-stage chronic obstructive pulmonary disease. However, the choice between single and double lung transplantation for these patients remains a matter of debate. Therefore, we performed a systematic search of medical databases for studies on single lung transplantation, double lung transplantation, and chronic obstructive pulmonary disease.
The rate ratio and hazard ratio of survival were analyzed. The meta-analysis included 15 case-control and retrospective registry studies.
The rate ratios of the 3-year survival (0.937 and P = 0.041) and 5-year survival (0.775 and P = 0.000) were lower for single lung transplantation than for double lung transplantation. However, the hazard ratio did not differ significantly between the two.
Double lung transplantation was found to provide better benefits than single lung transplantation in terms of the long-term survival in patients with chronic obstructive pulmonary disease.