Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

[Display omitted] A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 26; no. 4; pp. 1329 - 1332
Main Authors:	Micheli, Fabrizio, Cremonesi, Susanna, Semeraro, Teresa, Tarsi, Luca, Tomelleri, Silvia, Cavanni, Paolo, Oliosi, Beatrice, Perdonà, Elisabetta, Sava, Anna, Zonzini, Laura, Feriani, Aldo, Braggio, Simone, Heidbreder, Christian
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 15-02-2016
Subjects:	7-TM Animals Antagonist Binding Sites DA D3 receptor Dopamine Dopamine D2 Receptor Antagonists - chemical synthesis Dopamine D2 Receptor Antagonists - chemistry Dopamine D2 Receptor Antagonists - pharmacokinetics Half-Life Molecular Docking Simulation Morpholine Morpholines - chemical synthesis Morpholines - chemistry Morpholines - pharmacokinetics Protein Structure, Tertiary Rats Receptors, Dopamine D3 - antagonists & inhibitors Receptors, Dopamine D3 - metabolism Morpholine DA D3 receptor Dopamine Antagonist 7-TM
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Description
Summary:	[Display omitted] A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2015.12.081