Patterns of cilia gene dysregulations in major psychiatric disorders
Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairment...
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| Published in: | Progress in neuro-psychopharmacology & biological psychiatry Vol. 109; p. 110255 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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13-07-2021
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| Abstract | Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the largest and most recent publicly available databases. We found that 42%, 24%, 17%, and 15% of brain-expressed cilia genes were significantly differentially expressed in SCZ, ASD, BP, and MDD, respectively. Several genes exhibited cross-disorder overlap, suggesting that typical cilia signaling pathways' dysfunctions determine susceptibility to more than one psychiatric disorder or may partially underlie their pathophysiology. Our study revealed that genes encoding proteins of almost all sub-cilia structural and functional compartments were dysregulated in the four psychiatric disorders. Strikingly, the genes of 75% of cilia GPCRs and 50% of the transition zone proteins were differentially expressed in SCZ.
The present study is the first to draw associations between cilia and major psychiatric disorders, and is the first step toward understanding the role that cilia components play in their pathophysiological processes, which may lead to novel therapeutic targets for these disorders.
•Cilia genes’ mutations that cause ciliopathies are associated with neurological defect such as cognitive dysfunctions•We demonstrate primary cilia’ gene dysregulations in major psychiatric disorders: schizophrenia, autism, bipolar disorder, and depression•We provide an evidence for primary cilia’ potential role as possible pathophysiological cause or therapeutic target in psychiatric disorders |
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| AbstractList | Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the largest and most recent publicly available databases. We found that 42%, 24%, 17%, and 15% of brain-expressed cilia genes were significantly differentially expressed in SCZ, ASD, BP, and MDD, respectively. Several genes exhibited cross-disorder overlap, suggesting that typical cilia signaling pathways' dysfunctions determine susceptibility to more than one psychiatric disorder or may partially underlie their pathophysiology. Our study revealed that genes encoding proteins of almost all sub-cilia structural and functional compartments were dysregulated in the four psychiatric disorders. Strikingly, the genes of 75% of cilia GPCRs and 50% of the transition zone proteins were differentially expressed in SCZ. The present study is the first to draw associations between cilia and major psychiatric disorders, and is the first step toward understanding the role that cilia components play in their pathophysiological processes, which may lead to novel therapeutic targets for these disorders. Primary cilia function as cells’ antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive deficits. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the largest and most recent publicly available databases. We found that 42%, 24%, 17%, and 15% of brain cilia genes were significantly differentially expressed in SCZ, ASD, BP, and MDD, respectively. Several genes exhibited cross-disorder overlap, suggesting that typical cilia signaling pathways’ dysfunctions determine susceptibility to more than one psychiatric disorder or may partially underlie their pathophysiology. Our study revealed that genes encoding proteins of almost all sub-cilia structural and functional compartments were dysregulated in the four psychiatric disorders. Strikingly, the genes of 75% of cilia GPCRs and 50% of the transition zone proteins were differentially expressed in SCZ. The present study is the first to draw associations between cilia and major psychiatric disorders, and is the first step toward understanding the role that cilia components play in their pathophysiological processes, which may lead to novel therapeutic targets for these disorders. Primary cilia function as cells' antennas to detect and transduce external stimuli and play crucial roles in cell signaling and communication. The vast majority of cilia genes that are causally linked with ciliopathies are also associated with neurological deficits, such as cognitive impairments. Yet, the roles of cilia dysfunctions in the pathogenesis of psychiatric disorders have not been studied. Our aim is to identify patterns of cilia gene dysregulation in the four major psychiatric disorders: schizophrenia (SCZ), autism spectrum disorder (ASD), bipolar disorder (BP), and major depressive disorder (MDD). For this purpose, we acquired differentially expressed genes (DEGs) from the largest and most recent publicly available databases. We found that 42%, 24%, 17%, and 15% of brain-expressed cilia genes were significantly differentially expressed in SCZ, ASD, BP, and MDD, respectively. Several genes exhibited cross-disorder overlap, suggesting that typical cilia signaling pathways' dysfunctions determine susceptibility to more than one psychiatric disorder or may partially underlie their pathophysiology. Our study revealed that genes encoding proteins of almost all sub-cilia structural and functional compartments were dysregulated in the four psychiatric disorders. Strikingly, the genes of 75% of cilia GPCRs and 50% of the transition zone proteins were differentially expressed in SCZ. The present study is the first to draw associations between cilia and major psychiatric disorders, and is the first step toward understanding the role that cilia components play in their pathophysiological processes, which may lead to novel therapeutic targets for these disorders. •Cilia genes’ mutations that cause ciliopathies are associated with neurological defect such as cognitive dysfunctions•We demonstrate primary cilia’ gene dysregulations in major psychiatric disorders: schizophrenia, autism, bipolar disorder, and depression•We provide an evidence for primary cilia’ potential role as possible pathophysiological cause or therapeutic target in psychiatric disorders |
| ArticleNumber | 110255 |
| Author | Chen, Siwei Robbins, Brianna Kay Baldi, Pierre Nauli, Surya M. Civelli, Olivier Nguyen, Henry Alhassen, Wedad Schulmann, Anton Alachkar, Amal Vawter, Marquis Myint, Thant Nyi Saito, Yumiko |
| AuthorAffiliation | 4 Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, USA 6 Human Genetics Branch, National Institute of Mental Health, BETHESDA MD 20814, USA 3 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California-Irvine, CA 92697, USA 8 Department of Developmental and Cell Biology, School of Biological Sciences, University of California-Irvine, CA 92697, USA 5 Graduate School of Integrated Arts and Sciences for Life, Hiroshima University, Japan 7 Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Health Science Campus, Chapman University, Irvine, California 92618, USA 1 Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA 92697, USA 2 Department of Computer Science, School of Information and Computer Sciences, University of California-Irvine, Irvine, CA 92697, USA |
| AuthorAffiliation_xml | – name: 5 Graduate School of Integrated Arts and Sciences for Life, Hiroshima University, Japan – name: 1 Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-Irvine, CA 92697, USA – name: 3 Institute for Genomics and Bioinformatics, School of Information and Computer Sciences, University of California-Irvine, CA 92697, USA – name: 7 Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Health Science Campus, Chapman University, Irvine, California 92618, USA – name: 8 Department of Developmental and Cell Biology, School of Biological Sciences, University of California-Irvine, CA 92697, USA – name: 2 Department of Computer Science, School of Information and Computer Sciences, University of California-Irvine, Irvine, CA 92697, USA – name: 4 Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, USA – name: 6 Human Genetics Branch, National Institute of Mental Health, BETHESDA MD 20814, USA |
| Author_xml | – sequence: 1 givenname: Wedad surname: Alhassen fullname: Alhassen, Wedad organization: Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-, Irvine, CA 92697, USA – sequence: 2 givenname: Siwei surname: Chen fullname: Chen, Siwei organization: Department of Computer Science, School of Information and Computer Sciences, University of California-Irvine, Irvine, CA 92697, USA – sequence: 3 givenname: Marquis surname: Vawter fullname: Vawter, Marquis organization: Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, USA – sequence: 4 givenname: Brianna Kay surname: Robbins fullname: Robbins, Brianna Kay organization: Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-, Irvine, CA 92697, USA – sequence: 5 givenname: Henry surname: Nguyen fullname: Nguyen, Henry organization: Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-, Irvine, CA 92697, USA – sequence: 6 givenname: Thant Nyi surname: Myint fullname: Myint, Thant Nyi organization: Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-, Irvine, CA 92697, USA – sequence: 7 givenname: Yumiko surname: Saito fullname: Saito, Yumiko organization: Graduate School of Integrated Sciences for Life, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8521, Japan – sequence: 8 givenname: Anton surname: Schulmann fullname: Schulmann, Anton organization: Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, USA – sequence: 9 givenname: Surya M. surname: Nauli fullname: Nauli, Surya M. organization: Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Health Science Campus, Irvine, CA 92618, USA – sequence: 10 givenname: Olivier surname: Civelli fullname: Civelli, Olivier organization: Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-, Irvine, CA 92697, USA – sequence: 11 givenname: Pierre surname: Baldi fullname: Baldi, Pierre organization: Department of Computer Science, School of Information and Computer Sciences, University of California-Irvine, Irvine, CA 92697, USA – sequence: 12 givenname: Amal surname: Alachkar fullname: Alachkar, Amal email: aalachka@uci.edu organization: Departments of Pharmaceutical Sciences, School of Pharmacy, University of California-, Irvine, CA 92697, USA |
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| Cites_doi | 10.1038/nn.4399 10.1002/ajmg.b.31088 10.1016/j.cellbi.2003.11.008 10.1016/S0140-6736(12)62129-1 10.1016/j.cell.2019.11.020 10.1073/pnas.0711027105 10.1016/j.ceb.2018.03.004 10.1186/2046-2530-1-7 10.1007/s00018-010-0603-4 10.1097/MNH.0000000000000251 10.1007/s00439-016-1755-6 10.1093/hmg/ddp335 10.1091/mbc.e06-02-0133 10.1016/S0006-8993(00)02519-1 10.1146/annurev-pharmtox-010611-134548 10.1534/genetics.109.101915 10.1093/jb/mvx087 10.3390/genes8020048 10.1371/journal.pone.0160216 10.1016/j.neuron.2012.10.027 10.1016/j.neuroscience.2020.07.015 10.1016/j.neulet.2016.08.050 10.1016/j.neures.2015.02.002 10.1001/archpsyc.63.8.844 10.1083/jcb.143.6.1591 10.1016/S0960-9822(01)00122-1 10.1038/sj.ejhg.5201848 10.1021/acs.nanolett.8b04138 10.1038/nrm.2017.60 10.1016/S0896-6273(04)00268-5 10.1242/dev.128.9.1493 10.1093/hmg/ddp113 10.1159/000337298 10.1371/journal.pone.0128422 10.1152/ajplung.00180.2002 10.1038/nature10523 10.1101/gad.1966210 10.1016/j.schres.2017.08.055 10.1002/hipo.20938 10.1016/j.cell.2006.12.017 10.1016/j.cell.2009.03.023 10.1016/S0306-4522(98)00354-6 10.1016/j.cell.2009.12.011 10.1177/0022034514528211 10.1038/s41573-019-0039-y 10.1038/ng.380 10.1371/journal.pone.0090980 10.1083/jcb.151.3.709 10.1038/s41467-020-19637-5 10.1016/j.tig.2009.10.003 10.1093/hmg/ddn291 10.1016/j.febslet.2015.05.007 10.1038/nature02061 10.1002/ajmg.b.31162 10.1083/jcb.153.1.13 10.1016/j.bbamem.2006.09.025 10.1093/hmg/ddq009 10.1126/science.aad6469 10.15252/embr.201540530 10.1002/dneu.22542 10.1016/j.biopsych.2005.05.040 10.1038/mp.2009.13 10.1016/j.celrep.2012.11.017 10.1038/mp.2008.128 10.1038/mp.2010.109 10.1016/j.molmed.2018.02.004 10.1186/2046-2530-3-9 10.1038/nrneurol.2013.247 10.1093/database/bap022 10.1016/j.gde.2009.04.008 10.1371/journal.pone.0216705 10.1038/nature20612 10.1371/journal.pone.0110484 10.1016/j.ajhg.2014.03.009 10.1016/j.ceb.2016.02.008 10.1001/archpsyc.65.9.996 10.1016/j.biopsych.2015.12.012 10.1016/j.ydbio.2006.09.001 10.1016/S0960-9822(01)00485-7 10.1073/pnas.1221011110 10.1021/acsnano.9b00033 10.1371/journal.pone.0099892 10.1016/j.neuron.2011.03.002 10.1038/s41398-019-0488-4 10.1038/ng2038 10.1016/j.ejmg.2018.07.012 |
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| Keywords | Autism DEGs Compartments Schizophrenia Bipolar disorder Depression Cilia |
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| References | Romaniello, Arrigoni, Fry, Bassi, Rees, Borgatti, Pilz, Cushion (bb0390) 2018; 61 Christensen, Morthorst, Mogensen (bb0070) 2017 Follit, Tuft, Fogarty, Pazour (bb0115) 2006; 17 Kang, Kawasawa, Cheng, Zhu, Xu, Li, Sousa, Pletikos, Meyer, Sedmak (bb0240) 2011; 478 Jaglin, Poirier, Saillour, Buhler, Tian, Bahi-Buisson, Fallet-Bianco, Phan-Dinh-Tuy, Kong, Bomont (bb0230) 2009; 41 Roberts, Hedlund (bb0385) 2012; 22 Nachury (bb0310) 2018; 51 Bassilana, Nash, Ludwig (bb0020) 2019; 18 Hsiao, Tong, Westfall, Ault, Page-McCaw, Ferland (bb0190) 2009; 18 Lancaster, Gleeson (bb0255) 2009; 19 Moens, Ceulemans, Alaerts, Van Den Bossche, Lenaerts, De Zutter, Norrback, Adolfsson, Del-Favero (bb0285) 2010; 153B Leung, Wong (bb0265) 2017 Hartwig, Monis, Chen, Dickman, Pazour, Faundez (bb0165) 2018; 78 Pala, Mohieldin, Sherpa, Kathem, Shamloo, Luan, Zhou, Zheng, Ahsan, Nauli (bb0345) 2019; 13 Alvarez Retuerto, Cantor, Gleeson, Ustaszewska, Schackwitz, Pennacchio, Geschwind (bb0005) 2008; 17 Breuss, Heng, Poirier, Tian, Jaglin, Qu, Braun, Gstrein, Ngo, Haas (bb0050) 2012; 2 van Dam, Townsend, Turk, Schlessinger, Sali, Field, Huynen (bb0430) 2013; 110 Varela, Horvath (bb0440) 2018; 24 Ren, Qiu, Zhang, Huang, Rao (bb0380) 2016; 632 Keays, Tian, Poirier, Huang, Siebold, Cleak, Oliver, Fray, Harvey, Molnar (bb0245) 2007; 128 May-Simera, Kelley (bb0280) 2012; 1 Datta, McQuillin, Rizig, Blaveri, Thirumalai, Kalsi, Lawrence, Bass, Puri, Choudhury (bb0095) 2010; 15 Catapano, Manji (bb0055) 2007; 1768 Hilgendorf, Johnson, Jackson (bb0175) 2016; 39 Nauli, Pala, Kleene (bb0325) 2016; 25 Guan, Cai, Ji, Sham (bb0145) 2019; 9 Tsujikawa, Malicki (bb0415) 2004; 42 Huangfu, Liu, Rakeman, Murcia, Niswander, Anderson (bb0200) 2003; 426 Nakayama, Katoh (bb0315) 2018; 163 Tischfield, Baris, Wu, Rudolph, Van Maldergem, He, Chan, Andrews, Demer, Robertson (bb0405) 2010; 140 Legue, Liem (bb0260) 2020; 450 Piperno, Siuda, Henderson, Segil, Vaananen, Sassaroli (bb0360) 1998; 143 Hines, Tabakoff, Trait (bb0180) 2005; 58 Norman, Ko, Huang, Eun, Abler, Zhang, Sun, Eggenschwiler (bb0330) 2009; 18 Zoubovsky, Oh, Cash-Padgett, Johnson, Hou, Mori, Gallagher, Katsanis, Sawa, Jaaro-Peled (bb0460) 2015; 98 Fromer, Roussos, Sieberts, Johnson, Kavanagh, Perumal, Ruderfer, Oh, Topol, Shah (bb0120) 2016; 19 Fuchs, Schwark (bb0125) 2004; 28 Valente, Rosti, Gibbs, Gleeson (bb0425) 2014; 10 Arnaiz, Cohen, Tassin, Koll (bb0015) 2014; 3 Chen, Luo, Leng, Yang, Zweifel, Palmiter, Storm (bb0065) 2016; 80 Nauli (bb0320) 2017 Korvatska, Estes, Munson, Dawson, Bekris, Kohen, Yu, Schellenberg, Raskind (bb0250) 2011; 156B Haycraft, Swoboda, Taulman, Thomas, Yoder (bb0170) 2001; 128 Munoz-Estrada, Lora-Castellanos, Meza, Alarcon Elizalde, Benitez-King (bb0305) 2018; 195 Baudoin, Viou, Launay, Luccardini, Espeso Gil, Kiyasova, Irinopoulou, Alvarez, Rio, Boudier (bb0025) 2012; 76 Mukhopadhyay, Wen, Chih, Nelson, Lane, Scales, Jackson (bb0295) 2010; 24 Gandal, Zhang, Hadjimichael, Walker, Chen, Liu, Won, van Bakel, Varghese, Wang (bb0130) 2018 Monroe TO, Garrett, Kousi, Rodriguiz, Moon, Bai, Brodar, Soldano, Savage, Hansen (bb0290) 2020; 11 Gerdes, Davis, Katsanis (bb0140) 2009; 137 Ingason, Giegling, Cichon, Hansen, Rasmussen, Nielsen, Jurgens, Muglia, Hartmann, Strengman (bb0210) 2010; 19 Cross-Disorder Group of the Psychiatric Genomics Consortium (bb0085) 2019; 179 Schneider, Mayer, El Hajj, Jensen, Kuss, Zischler, Kondova, Bontrop, Navarro, Fuchs (bb0395) 2012; 136 Cushion, Paciorkowski, Pilz, Mullins, Seltzer, Marion, Tuttle, Ghoneim, Christian, Chung (bb0090) 2014; 94 Liu, Chen, Cheng, Jing, Helms (bb0270) 2014; 93 Qin, Rosenbaum, Barr (bb0365) 2001; 11 Houde, Dickinson, Houtzager, Cullum, Montpetit, Metzler, Simpson, Roy, Hayden, Hoodless (bb0185) 2006; 300 Arnaiz, Malinowska, Klotz, Sperling, Dadlez, Koll, Cohen (bb0010) 2009 Cross-Disorder Group of the Psychiatric Genomics C (bb0080) 2013; 381 Domire, Green, Lee, Johnson, Askwith, Mykytyn (bb0100) 2011; 68 Louvi, Grove (bb0275) 2011; 69 Eastwood, Hodgkinson, Harrison (bb0105) 2009; 14 Gurling, Critchley, Datta, McQuillin, Blaveri, Thirumalai, Pimm, Krasucki, Kalsi, Quested (bb0155) 2006; 63 Wray, Pergadia, Blackwood, Penninx, Gordon, Nyholt, Ripke, MacIntyre, McGhee, Maclean (bb0450) 2012; 17 van Dam, Kennedy, van der Lee, de Vrieze, Wunderlich, Rix, Dougherty, Lambacher, Li, Jensen (bb0435) 2019; 14 Berbari, Lewis, Bishop, Askwith, Mykytyn (bb0035) 2008; 105 Chang, Jamain, Lin, Rujescu, Tseng, Sibille (bb0060) 2014; 9 Brailov, Bancila, Brisorgueil, Miquel, Hamon, Verge (bb0040) 2000; 872 Evans, Fanucchi, Van Winkle, Baker, Murphy, Nishio, Sannes, Plopper (bb0110) 2002; 283 Handel, Schulz, Stanarius, Schreff, Erdtmann-Vourliotis, Schmidt, Wolf, Hollt (bb0160) 1999; 89 Gurling, Critchley, Datta, McQuillin, Blaveri, Thirumalai, Pimm, Krasucki, Kalsi, Quested (bb0150) 2006; 63 Reiter, Leroux (bb0375) 2017; 18 Schou, Pedersen, Christensen (bb0400) 2015; 16 Jaglin, Chelly (bb0225) 2009; 25 Kamiya, Tan, Kubo, Engelhard, Ishizuka, Kubo, Tsukita, Pulver, Nakajima, Cascella (bb0235) 2008; 65 Zhao, Nyholt (bb0455) 2017; 136 Parikshak, Swarup, Belgard, Irimia, Ramaswami, Gandal, Hartl, Leppa, Ubieta, Huang (bb0350) 2016; 540 Rampino, Walker, Torrance, Anderson, Fazio, Di Giorgio, Taurisano, Gelao, Romano, Masellis (bb0370) 2014; 9 Brazelton, Amundsen, Silflow, Lefebvre (bb0045) 2001; 11 Iomini, Babaev-Khaimov, Sassaroli, Piperno (bb0215) 2001; 153 Mukhopadhyay, Wen, Chih, Nelson, Lane, Scales, Jackson (bb0300) 2010; 24 Trulioff, Ermakov, Malashichev (bb0410) 2017; 8 Pazour, Dickert, Vucica, Seeleye, Rosenbaum, Witman, Cole (bb0355) 2000; 151 Ingason, Sigmundsson, Steinberg, Sigurdsson, Haraldsson, Magnusdottir, Frigge, Kong, Gulcher, Thorsteinsdottir (bb0205) 2007; 15 Valencia-Gattas, Conner, Fregien (bb0420) 2016; 11 Verleyen, Luyten, Tylzanowski (bb0445) 2014; 9 Beales, Bland, Tobin, Bacchelli, Tuysuz, Hill, Rix, Pearson, Kai, Hartley (bb0030) 2007; 39 Iomini, Li, Esparza, Dutcher (bb0220) 2009; 183 Civelli, Reinscheid, Zhang, Wang, Fredriksson, Schioth (bb0075) 2013; 53 Gandal, Haney, Parikshak, Leppa, Ramaswami, Hartl, Schork, Appadurai, Buil, Werge (bb0135) 2018; 359 Huang, Thathiah (bb0195) 2015; 589 Pala, Mohieldin, Shamloo, Sherpa, Kathem, Zhou, Luan, Zheng, Ahsan, Nauli (bb0340) 2019; 19 Omori, Chaya, Yoshida, Irie, Tsujii, Furukawa (bb0335) 2015; 10 Alvarez Retuerto (10.1016/j.pnpbp.2021.110255_bb0005) 2008; 17 Breuss (10.1016/j.pnpbp.2021.110255_bb0050) 2012; 2 Chen (10.1016/j.pnpbp.2021.110255_bb0065) 2016; 80 Huangfu (10.1016/j.pnpbp.2021.110255_bb0200) 2003; 426 Nauli (10.1016/j.pnpbp.2021.110255_bb0325) 2016; 25 Fromer (10.1016/j.pnpbp.2021.110255_bb0120) 2016; 19 Houde (10.1016/j.pnpbp.2021.110255_bb0185) 2006; 300 Valencia-Gattas (10.1016/j.pnpbp.2021.110255_bb0420) 2016; 11 Ren (10.1016/j.pnpbp.2021.110255_bb0380) 2016; 632 Rampino (10.1016/j.pnpbp.2021.110255_bb0370) 2014; 9 Domire (10.1016/j.pnpbp.2021.110255_bb0100) 2011; 68 Gandal (10.1016/j.pnpbp.2021.110255_bb0130) 2018 Eastwood (10.1016/j.pnpbp.2021.110255_bb0105) 2009; 14 Mukhopadhyay (10.1016/j.pnpbp.2021.110255_bb0300) 2010; 24 Zoubovsky (10.1016/j.pnpbp.2021.110255_bb0460) 2015; 98 Brailov (10.1016/j.pnpbp.2021.110255_bb0040) 2000; 872 Verleyen (10.1016/j.pnpbp.2021.110255_bb0445) 2014; 9 Mukhopadhyay (10.1016/j.pnpbp.2021.110255_bb0295) 2010; 24 Jaglin (10.1016/j.pnpbp.2021.110255_bb0225) 2009; 25 Civelli (10.1016/j.pnpbp.2021.110255_bb0075) 2013; 53 Omori (10.1016/j.pnpbp.2021.110255_bb0335) 2015; 10 Louvi (10.1016/j.pnpbp.2021.110255_bb0275) 2011; 69 Bassilana (10.1016/j.pnpbp.2021.110255_bb0020) 2019; 18 Pala (10.1016/j.pnpbp.2021.110255_bb0340) 2019; 19 Valente (10.1016/j.pnpbp.2021.110255_bb0425) 2014; 10 Korvatska (10.1016/j.pnpbp.2021.110255_bb0250) 2011; 156B Gerdes (10.1016/j.pnpbp.2021.110255_bb0140) 2009; 137 Brazelton (10.1016/j.pnpbp.2021.110255_bb0045) 2001; 11 Norman (10.1016/j.pnpbp.2021.110255_bb0330) 2009; 18 Cross-Disorder Group of the Psychiatric Genomics C (10.1016/j.pnpbp.2021.110255_bb0080) 2013; 381 Zhao (10.1016/j.pnpbp.2021.110255_bb0455) 2017; 136 Gandal (10.1016/j.pnpbp.2021.110255_bb0135) 2018; 359 Gurling (10.1016/j.pnpbp.2021.110255_bb0150) 2006; 63 Lancaster (10.1016/j.pnpbp.2021.110255_bb0255) 2009; 19 Christensen (10.1016/j.pnpbp.2021.110255_bb0070) 2017 Varela (10.1016/j.pnpbp.2021.110255_bb0440) 2018; 24 Jaglin (10.1016/j.pnpbp.2021.110255_bb0230) 2009; 41 Moens (10.1016/j.pnpbp.2021.110255_bb0285) 2010; 153B Ingason (10.1016/j.pnpbp.2021.110255_bb0210) 2010; 19 Schneider (10.1016/j.pnpbp.2021.110255_bb0395) 2012; 136 Huang (10.1016/j.pnpbp.2021.110255_bb0195) 2015; 589 Munoz-Estrada (10.1016/j.pnpbp.2021.110255_bb0305) 2018; 195 Beales (10.1016/j.pnpbp.2021.110255_bb0030) 2007; 39 Liu (10.1016/j.pnpbp.2021.110255_bb0270) 2014; 93 Baudoin (10.1016/j.pnpbp.2021.110255_bb0025) 2012; 76 Cross-Disorder Group of the Psychiatric Genomics Consortium (10.1016/j.pnpbp.2021.110255_bb0085) 2019; 179 Keays (10.1016/j.pnpbp.2021.110255_bb0245) 2007; 128 May-Simera (10.1016/j.pnpbp.2021.110255_bb0280) 2012; 1 Cushion (10.1016/j.pnpbp.2021.110255_bb0090) 2014; 94 Fuchs (10.1016/j.pnpbp.2021.110255_bb0125) 2004; 28 Kamiya (10.1016/j.pnpbp.2021.110255_bb0235) 2008; 65 Datta (10.1016/j.pnpbp.2021.110255_bb0095) 2010; 15 Hilgendorf (10.1016/j.pnpbp.2021.110255_bb0175) 2016; 39 Romaniello (10.1016/j.pnpbp.2021.110255_bb0390) 2018; 61 Chang (10.1016/j.pnpbp.2021.110255_bb0060) 2014; 9 Reiter (10.1016/j.pnpbp.2021.110255_bb0375) 2017; 18 Catapano (10.1016/j.pnpbp.2021.110255_bb0055) 2007; 1768 Tsujikawa (10.1016/j.pnpbp.2021.110255_bb0415) 2004; 42 Pala (10.1016/j.pnpbp.2021.110255_bb0345) 2019; 13 Monroe TO (10.1016/j.pnpbp.2021.110255_bb0290) 2020; 11 Haycraft (10.1016/j.pnpbp.2021.110255_bb0170) 2001; 128 Iomini (10.1016/j.pnpbp.2021.110255_bb0220) 2009; 183 Schou (10.1016/j.pnpbp.2021.110255_bb0400) 2015; 16 Berbari (10.1016/j.pnpbp.2021.110255_bb0035) 2008; 105 Hartwig (10.1016/j.pnpbp.2021.110255_bb0165) 2018; 78 Pazour (10.1016/j.pnpbp.2021.110255_bb0355) 2000; 151 Trulioff (10.1016/j.pnpbp.2021.110255_bb0410) 2017; 8 Piperno (10.1016/j.pnpbp.2021.110255_bb0360) 1998; 143 Follit (10.1016/j.pnpbp.2021.110255_bb0115) 2006; 17 Nachury (10.1016/j.pnpbp.2021.110255_bb0310) 2018; 51 Hines (10.1016/j.pnpbp.2021.110255_bb0180) 2005; 58 Iomini (10.1016/j.pnpbp.2021.110255_bb0215) 2001; 153 Arnaiz (10.1016/j.pnpbp.2021.110255_bb0010) 2009 Handel (10.1016/j.pnpbp.2021.110255_bb0160) 1999; 89 Tischfield (10.1016/j.pnpbp.2021.110255_bb0405) 2010; 140 Gurling (10.1016/j.pnpbp.2021.110255_bb0155) 2006; 63 Qin (10.1016/j.pnpbp.2021.110255_bb0365) 2001; 11 Parikshak (10.1016/j.pnpbp.2021.110255_bb0350) 2016; 540 Wray (10.1016/j.pnpbp.2021.110255_bb0450) 2012; 17 Hsiao (10.1016/j.pnpbp.2021.110255_bb0190) 2009; 18 Kang (10.1016/j.pnpbp.2021.110255_bb0240) 2011; 478 Leung (10.1016/j.pnpbp.2021.110255_bb0265) 2017 Nakayama (10.1016/j.pnpbp.2021.110255_bb0315) 2018; 163 Roberts (10.1016/j.pnpbp.2021.110255_bb0385) 2012; 22 van Dam (10.1016/j.pnpbp.2021.110255_bb0430) 2013; 110 Legue (10.1016/j.pnpbp.2021.110255_bb0260) 2020; 450 Arnaiz (10.1016/j.pnpbp.2021.110255_bb0015) 2014; 3 Ingason (10.1016/j.pnpbp.2021.110255_bb0205) 2007; 15 Guan (10.1016/j.pnpbp.2021.110255_bb0145) 2019; 9 Nauli (10.1016/j.pnpbp.2021.110255_bb0320) 2017 van Dam (10.1016/j.pnpbp.2021.110255_bb0435) 2019; 14 Evans (10.1016/j.pnpbp.2021.110255_bb0110) 2002; 283 |
| References_xml | – volume: 151 start-page: 709 year: 2000 end-page: 718 ident: bb0355 article-title: Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella publication-title: J. Cell Biol. contributor: fullname: Cole – volume: 17 start-page: 36 year: 2012 end-page: 48 ident: bb0450 article-title: Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned publication-title: Mol. Psychiatry contributor: fullname: Maclean – volume: 156B start-page: 303 year: 2011 end-page: 311 ident: bb0250 article-title: Mutations in the TSGA14 gene in families with autism spectrum disorders publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. contributor: fullname: Raskind – volume: 25 start-page: 555 year: 2009 end-page: 566 ident: bb0225 article-title: Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects publication-title: Trends Genet. contributor: fullname: Chelly – volume: 17 start-page: 3887 year: 2008 end-page: 3896 ident: bb0005 article-title: Association of common variants in the Joubert syndrome gene (AHI1) with autism publication-title: Hum. Mol. Genet. contributor: fullname: Geschwind – volume: 24 start-page: 2180 year: 2010 end-page: 2193 ident: bb0295 article-title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia publication-title: Genes Dev. contributor: fullname: Jackson – volume: 41 start-page: 746 year: 2009 end-page: 752 ident: bb0230 article-title: Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria publication-title: Nat. Genet. contributor: fullname: Bomont – volume: 9 start-page: 152 year: 2019 ident: bb0145 article-title: Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder publication-title: Transl. Psychiatry contributor: fullname: Sham – volume: 872 start-page: 271 year: 2000 end-page: 275 ident: bb0040 article-title: Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain publication-title: Brain Res. contributor: fullname: Verge – volume: 8 year: 2017 ident: bb0410 article-title: Primary cilia as a possible link between left-right asymmetry and neurodevelopmental diseases publication-title: Genes contributor: fullname: Malashichev – volume: 18 start-page: 1740 year: 2009 end-page: 1754 ident: bb0330 article-title: Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of hedgehog signaling publication-title: Hum. Mol. Genet. contributor: fullname: Eggenschwiler – volume: 68 start-page: 2951 year: 2011 end-page: 2960 ident: bb0100 article-title: Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins publication-title: Cellular and molecular life sciences : CMLS contributor: fullname: Mykytyn – volume: 69 start-page: 1046 year: 2011 end-page: 1060 ident: bb0275 article-title: Cilia in the CNS: the quiet organelle claims center stage publication-title: Neuron contributor: fullname: Grove – volume: 78 start-page: 311 year: 2018 end-page: 330 ident: bb0165 article-title: Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes publication-title: Developmental Neurobiol. contributor: fullname: Faundez – volume: 426 start-page: 83 year: 2003 end-page: 87 ident: bb0200 article-title: Hedgehog signalling in the mouse requires intraflagellar transport proteins publication-title: Nature contributor: fullname: Anderson – volume: 19 start-page: 220 year: 2009 end-page: 229 ident: bb0255 article-title: The primary cilium as a cellular signaling center: lessons from disease publication-title: Curr. Opin. Genet. Dev. contributor: fullname: Gleeson – volume: 136 start-page: 278 year: 2012 end-page: 287 ident: bb0395 article-title: Methylation and expression analyses of the 7q autism susceptibility locus genes MEST, COPG2, and TSGA14 in human and anthropoid primate cortices publication-title: Cytogenetic and genome research contributor: fullname: Fuchs – volume: 16 start-page: 1099 year: 2015 end-page: 1113 ident: bb0400 article-title: Ins and outs of GPCR signaling in primary cilia publication-title: EMBO Rep. contributor: fullname: Christensen – volume: 89 start-page: 909 year: 1999 end-page: 926 ident: bb0160 article-title: Selective targeting of somatostatin receptor 3 to neuronal cilia publication-title: Neuroscience contributor: fullname: Hollt – volume: 25 start-page: 452 year: 2016 end-page: 458 ident: bb0325 article-title: Calcium channels in primary cilia publication-title: Curr. Opin. Nephrol. Hypertens. contributor: fullname: Kleene – volume: 94 start-page: 634 year: 2014 end-page: 641 ident: bb0090 article-title: De novo mutations in the Beta-tubulin gene TUBB2A cause simplified Gyral patterning and infantile-onset epilepsy publication-title: Am. J. Hum. Genet. contributor: fullname: Chung – volume: 51 start-page: 124 year: 2018 end-page: 131 ident: bb0310 article-title: The molecular machines that traffic signaling receptors into and out of cilia publication-title: Curr. Opin. Cell Biol. contributor: fullname: Nachury – volume: 42 start-page: 703 year: 2004 end-page: 716 ident: bb0415 article-title: Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons publication-title: Neuron contributor: fullname: Malicki – volume: 11 start-page: 1591 year: 2001 end-page: 1594 ident: bb0045 article-title: The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly publication-title: Curr. Biol. contributor: fullname: Lefebvre – volume: 9 year: 2014 ident: bb0060 article-title: A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies publication-title: PLoS One contributor: fullname: Sibille – volume: 19 start-page: 1442 year: 2016 end-page: 1453 ident: bb0120 article-title: Gene expression elucidates functional impact of polygenic risk for schizophrenia publication-title: Nat. Neurosci. contributor: fullname: Shah – volume: 18 start-page: 3926 year: 2009 end-page: 3941 ident: bb0190 article-title: Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking publication-title: Hum. Mol. Genet. contributor: fullname: Ferland – volume: 18 start-page: 533 year: 2017 end-page: 547 ident: bb0375 article-title: Genes and molecular pathways underpinning ciliopathies publication-title: Nat. Rev. Mol. Cell Biol. contributor: fullname: Leroux – volume: 19 start-page: 904 year: 2019 end-page: 914 ident: bb0340 article-title: Personalized Nanotherapy by specifically targeting cell organelles to improve vascular hypertension publication-title: Nano Lett. contributor: fullname: Nauli – volume: 478 start-page: 483 year: 2011 end-page: 489 ident: bb0240 article-title: Spatio-temporal transcriptome of the human brain publication-title: Nature contributor: fullname: Sedmak – volume: 93 start-page: 475 year: 2014 end-page: 482 ident: bb0270 article-title: Primary cilia integrate hedgehog and Wnt signaling during tooth development publication-title: J. Dent. Res. contributor: fullname: Helms – volume: 140 start-page: 74 year: 2010 end-page: 87 ident: bb0405 article-title: Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance publication-title: Cell contributor: fullname: Robertson – volume: 110 start-page: 6943 year: 2013 end-page: 6948 ident: bb0430 article-title: Evolution of modular intraflagellar transport from a coatomer-like progenitor publication-title: P Natl Acad Sci USA contributor: fullname: Huynen – volume: 9 year: 2014 ident: bb0445 article-title: Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer’s vesicle publication-title: PLoS One contributor: fullname: Tylzanowski – volume: 105 start-page: 4242 year: 2008 end-page: 4246 ident: bb0035 article-title: Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Mykytyn – volume: 80 start-page: 836 year: 2016 end-page: 848 ident: bb0065 article-title: Ablation of type III adenylyl cyclase in mice causes reduced neuronal activity, altered sleep pattern, and depression-like phenotypes publication-title: Biol. Psychiatry contributor: fullname: Storm – start-page: 9(6) year: 2017 ident: bb0070 article-title: Pedersen LB: primary cilia and coordination of receptor tyrosine kinase (rtk) and transforming growth factor beta (TGF-beta) signaling publication-title: Cold Spring Harb. Perspect. Biol. contributor: fullname: Mogensen – volume: 1 start-page: 7 year: 2012 ident: bb0280 article-title: Cilia, Wnt signaling, and the cytoskeleton publication-title: Cilia contributor: fullname: Kelley – volume: 1768 start-page: 976 year: 2007 end-page: 993 ident: bb0055 article-title: G protein-coupled receptors in major psychiatric disorders publication-title: Biochim. Biophys. Acta contributor: fullname: Manji – volume: 381 start-page: 1371 year: 2013 end-page: 1379 ident: bb0080 article-title: Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis publication-title: Lancet contributor: fullname: Cross-Disorder Group of the Psychiatric Genomics C – volume: 11 start-page: 5903 year: 2020 ident: bb0290 article-title: PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia publication-title: Nat. Commun. contributor: fullname: Hansen – volume: 15 start-page: 615 year: 2010 end-page: 628 ident: bb0095 article-title: A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia publication-title: Mol. Psychiatry contributor: fullname: Choudhury – volume: 283 start-page: L1263 year: 2002 end-page: L1270 ident: bb0110 article-title: Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. contributor: fullname: Plopper – volume: 11 year: 2016 ident: bb0420 article-title: Gefitinib, an EGFR tyrosine kinase inhibitor, prevents smoke-mediated ciliated airway epithelial cell loss and promotes their recovery publication-title: PLoS One contributor: fullname: Fregien – year: 2009 ident: bb0010 article-title: Cildb: a knowledgebase for centrosomes and cilia publication-title: Database contributor: fullname: Cohen – volume: 39 start-page: 84 year: 2016 end-page: 92 ident: bb0175 article-title: The primary cilium as a cellular receiver: organizing ciliary GPCR signaling publication-title: Curr. Opin. Cell Biol. contributor: fullname: Jackson – year: 2017 ident: bb0320 article-title: SR, Reese CJ, Nauli AM: Mechanosensory and Chemosensory Primary Cilia in Ciliopathy and Ciliotherapy contributor: fullname: Nauli – volume: 22 start-page: 762 year: 2012 end-page: 771 ident: bb0385 article-title: The 5-HT(7) receptor in learning and memory publication-title: Hippocampus contributor: fullname: Hedlund – volume: 450 start-page: 3 year: 2020 end-page: 14 ident: bb0260 article-title: Mutations in ciliary trafficking genes affect sonic hedgehog-dependent neural tube patterning differentially along the anterior-posterior Axis publication-title: Neuroscience contributor: fullname: Liem – volume: 540 start-page: 423 year: 2016 end-page: 427 ident: bb0350 article-title: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism publication-title: Nature contributor: fullname: Huang – volume: 632 start-page: 130 year: 2016 end-page: 135 ident: bb0380 article-title: A cis-eQTL in AHI1 confers risk to schizophrenia in European populations publication-title: Neurosci. Lett. contributor: fullname: Rao – volume: 3 start-page: 9 year: 2014 ident: bb0015 article-title: Remodeling Cildb, a popular database for cilia and links for ciliopathies publication-title: Cilia contributor: fullname: Koll – volume: 183 start-page: 885 year: 2009 end-page: 896 ident: bb0220 article-title: Retrograde Intraflagellar transport mutants identify complex a proteins with multiple genetic interactions in Chlamydomonas reinhardtii publication-title: Genetics contributor: fullname: Dutcher – volume: 18 start-page: 869 year: 2019 end-page: 884 ident: bb0020 article-title: Adhesion G protein-coupled receptors: opportunities for drug discovery publication-title: Nat. Rev. Drug Discov. contributor: fullname: Ludwig – volume: 63 start-page: 844 year: 2006 end-page: 854 ident: bb0150 article-title: Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia publication-title: Arch. Gen. Psychiatry contributor: fullname: Quested – volume: 65 start-page: 996 year: 2008 end-page: 1006 ident: bb0235 article-title: Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses publication-title: Arch. Gen. Psychiatry contributor: fullname: Cascella – volume: 128 start-page: 45 year: 2007 end-page: 57 ident: bb0245 article-title: Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans publication-title: Cell contributor: fullname: Molnar – volume: 359 start-page: 693 year: 2018 end-page: 697 ident: bb0135 article-title: Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap publication-title: Science contributor: fullname: Werge – volume: 179 start-page: 1469 year: 2019 end-page: 1482 ident: bb0085 article-title: Electronic address pmhe, cross-disorder Group of the Psychiatric Genomics C: genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders publication-title: Cell contributor: fullname: Cross-Disorder Group of the Psychiatric Genomics Consortium – volume: 17 start-page: 3781 year: 2006 end-page: 3792 ident: bb0115 article-title: The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly publication-title: Mol. Biol. Cell contributor: fullname: Pazour – volume: 63 start-page: 844 year: 2006 end-page: 854 ident: bb0155 article-title: Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia publication-title: Arch. Gen. Psychiatry contributor: fullname: Quested – volume: 143 start-page: 1591 year: 1998 end-page: 1601 ident: bb0360 article-title: Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects publication-title: J. Cell Biol. contributor: fullname: Sassaroli – volume: 128 start-page: 1493 year: 2001 end-page: 1505 ident: bb0170 article-title: The C-elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms publication-title: Development contributor: fullname: Yoder – volume: 11 start-page: 457 year: 2001 end-page: 461 ident: bb0365 article-title: An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C-elegans ciliated sensory neurons publication-title: Curr. Biol. contributor: fullname: Barr – volume: 10 start-page: 27 year: 2014 end-page: 36 ident: bb0425 article-title: Primary cilia in neurodevelopmental disorders publication-title: Nat. Rev. Neurol. contributor: fullname: Gleeson – volume: 58 start-page: 955 year: 2005 end-page: 962 ident: bb0180 article-title: Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use publication-title: Biol. Psychiatry contributor: fullname: Trait – volume: 153B start-page: 1240 year: 2010 end-page: 1243 ident: bb0285 article-title: PCM1 and schizophrenia: a replication study in the northern Swedish population publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. contributor: fullname: Del-Favero – volume: 61 start-page: 744 year: 2018 end-page: 754 ident: bb0390 article-title: Tubulin genes and malformations of cortical development publication-title: Eur J Med Genet contributor: fullname: Cushion – volume: 24 start-page: 2180 year: 2010 end-page: 2193 ident: bb0300 article-title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia publication-title: Genes Dev. contributor: fullname: Jackson – volume: 98 start-page: 45 year: 2015 end-page: 49 ident: bb0460 article-title: Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1) publication-title: Neurosci. Res. contributor: fullname: Jaaro-Peled – start-page: 22(7) year: 2017 ident: bb0265 article-title: Role of G protein-coupled receptors in the regulation of structural plasticity and cognitive function publication-title: Molecules contributor: fullname: Wong – volume: 28 start-page: 111 year: 2004 end-page: 118 ident: bb0125 article-title: Neuronal primary cilia: a review publication-title: Cell Biol. Int. contributor: fullname: Schwark – volume: 195 start-page: 412 year: 2018 end-page: 420 ident: bb0305 article-title: Primary cilia formation is diminished in schizophrenia and bipolar disorder: a possible marker for these psychiatric diseases publication-title: Schizophr. Res. contributor: fullname: Benitez-King – volume: 137 start-page: 32 year: 2009 end-page: 45 ident: bb0140 article-title: The vertebrate primary cilium in development, homeostasis, and disease publication-title: Cell contributor: fullname: Katsanis – volume: 589 start-page: 1607 year: 2015 end-page: 1619 ident: bb0195 article-title: Regulation of neuronal communication by G protein-coupled receptors publication-title: FEBS Lett. contributor: fullname: Thathiah – volume: 136 start-page: 263 year: 2017 end-page: 274 ident: bb0455 article-title: Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders publication-title: Hum. Genet. contributor: fullname: Nyholt – volume: 76 start-page: 1108 year: 2012 end-page: 1122 ident: bb0025 article-title: Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate publication-title: Neuron contributor: fullname: Boudier – volume: 14 start-page: 556 year: 2009 end-page: 557 ident: bb0105 article-title: DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release publication-title: Mol. Psychiatry contributor: fullname: Harrison – volume: 10 year: 2015 ident: bb0335 article-title: Identification of G protein-coupled receptors (GPCRs) in primary cilia and their possible involvement in body weight control publication-title: PLoS One contributor: fullname: Furukawa – volume: 9 year: 2014 ident: bb0370 article-title: Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia publication-title: PLoS One contributor: fullname: Masellis – volume: 19 start-page: 1379 year: 2010 end-page: 1386 ident: bb0210 article-title: A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia publication-title: Hum. Mol. Genet. contributor: fullname: Strengman – volume: 163 start-page: 155 year: 2018 end-page: 164 ident: bb0315 article-title: Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors publication-title: J. Biochem. contributor: fullname: Katoh – volume: 13 start-page: 3555 year: 2019 end-page: 3572 ident: bb0345 article-title: Ciliotherapy: remote control of primary cilia movement and function by magnetic nanoparticles publication-title: ACS Nano contributor: fullname: Nauli – volume: 39 start-page: 727 year: 2007 end-page: 729 ident: bb0030 article-title: IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy publication-title: Nat. Genet. contributor: fullname: Hartley – volume: 15 start-page: 988 year: 2007 end-page: 991 ident: bb0205 article-title: Support for involvement of the AHI1 locus in schizophrenia publication-title: Eur. J. human genetics : EJHG contributor: fullname: Thorsteinsdottir – volume: 14 year: 2019 ident: bb0435 article-title: CiliaCarta: an integrated and validated compendium of ciliary genes publication-title: PLoS One contributor: fullname: Jensen – volume: 2 start-page: 1554 year: 2012 end-page: 1562 ident: bb0050 article-title: Mutations in the beta-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities publication-title: Cell Rep. contributor: fullname: Haas – volume: 153 start-page: 13 year: 2001 end-page: 24 ident: bb0215 article-title: Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases publication-title: J. Cell Biol. contributor: fullname: Piperno – volume: 300 start-page: 523 year: 2006 end-page: 533 ident: bb0185 article-title: Hippi is essential for node cilia assembly and sonic hedgehog signaling publication-title: Dev. Biol. contributor: fullname: Hoodless – start-page: 362(6420) year: 2018 ident: bb0130 article-title: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder publication-title: Science contributor: fullname: Wang – volume: 24 start-page: 333 year: 2018 end-page: 334 ident: bb0440 article-title: Neuronal cilia: another player in the Melanocortin system publication-title: Trends Mol. Med. contributor: fullname: Horvath – volume: 53 start-page: 127 year: 2013 end-page: 146 ident: bb0075 article-title: G protein-coupled receptor deorphanizations publication-title: Annu. Rev. Pharmacol. Toxicol. contributor: fullname: Schioth – volume: 19 start-page: 1442 issue: 11 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0120 article-title: Gene expression elucidates functional impact of polygenic risk for schizophrenia publication-title: Nat. Neurosci. doi: 10.1038/nn.4399 contributor: fullname: Fromer – volume: 153B start-page: 1240 issue: 6 year: 2010 ident: 10.1016/j.pnpbp.2021.110255_bb0285 article-title: PCM1 and schizophrenia: a replication study in the northern Swedish population publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. doi: 10.1002/ajmg.b.31088 contributor: fullname: Moens – volume: 28 start-page: 111 issue: 2 year: 2004 ident: 10.1016/j.pnpbp.2021.110255_bb0125 article-title: Neuronal primary cilia: a review publication-title: Cell Biol. Int. doi: 10.1016/j.cellbi.2003.11.008 contributor: fullname: Fuchs – volume: 381 start-page: 1371 issue: 9875 year: 2013 ident: 10.1016/j.pnpbp.2021.110255_bb0080 article-title: Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis publication-title: Lancet doi: 10.1016/S0140-6736(12)62129-1 contributor: fullname: Cross-Disorder Group of the Psychiatric Genomics C – volume: 179 start-page: 1469 issue: 7 year: 2019 ident: 10.1016/j.pnpbp.2021.110255_bb0085 article-title: Electronic address pmhe, cross-disorder Group of the Psychiatric Genomics C: genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders publication-title: Cell doi: 10.1016/j.cell.2019.11.020 contributor: fullname: Cross-Disorder Group of the Psychiatric Genomics Consortium – year: 2017 ident: 10.1016/j.pnpbp.2021.110255_bb0320 contributor: fullname: Nauli – volume: 105 start-page: 4242 issue: 11 year: 2008 ident: 10.1016/j.pnpbp.2021.110255_bb0035 article-title: Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0711027105 contributor: fullname: Berbari – volume: 51 start-page: 124 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0310 article-title: The molecular machines that traffic signaling receptors into and out of cilia publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2018.03.004 contributor: fullname: Nachury – volume: 1 start-page: 7 issue: 1 year: 2012 ident: 10.1016/j.pnpbp.2021.110255_bb0280 article-title: Cilia, Wnt signaling, and the cytoskeleton publication-title: Cilia doi: 10.1186/2046-2530-1-7 contributor: fullname: May-Simera – volume: 68 start-page: 2951 issue: 17 year: 2011 ident: 10.1016/j.pnpbp.2021.110255_bb0100 article-title: Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins publication-title: Cellular and molecular life sciences : CMLS doi: 10.1007/s00018-010-0603-4 contributor: fullname: Domire – volume: 25 start-page: 452 issue: 5 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0325 article-title: Calcium channels in primary cilia publication-title: Curr. Opin. Nephrol. Hypertens. doi: 10.1097/MNH.0000000000000251 contributor: fullname: Nauli – volume: 136 start-page: 263 issue: 2 year: 2017 ident: 10.1016/j.pnpbp.2021.110255_bb0455 article-title: Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders publication-title: Hum. Genet. doi: 10.1007/s00439-016-1755-6 contributor: fullname: Zhao – volume: 18 start-page: 3926 issue: 20 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0190 article-title: Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp335 contributor: fullname: Hsiao – volume: 17 start-page: 3781 issue: 9 year: 2006 ident: 10.1016/j.pnpbp.2021.110255_bb0115 article-title: The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly publication-title: Mol. Biol. Cell doi: 10.1091/mbc.e06-02-0133 contributor: fullname: Follit – volume: 872 start-page: 271 issue: 1–2 year: 2000 ident: 10.1016/j.pnpbp.2021.110255_bb0040 article-title: Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain publication-title: Brain Res. doi: 10.1016/S0006-8993(00)02519-1 contributor: fullname: Brailov – volume: 53 start-page: 127 year: 2013 ident: 10.1016/j.pnpbp.2021.110255_bb0075 article-title: G protein-coupled receptor deorphanizations publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev-pharmtox-010611-134548 contributor: fullname: Civelli – volume: 183 start-page: 885 issue: 3 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0220 article-title: Retrograde Intraflagellar transport mutants identify complex a proteins with multiple genetic interactions in Chlamydomonas reinhardtii publication-title: Genetics doi: 10.1534/genetics.109.101915 contributor: fullname: Iomini – volume: 163 start-page: 155 issue: 3 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0315 article-title: Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors publication-title: J. Biochem. doi: 10.1093/jb/mvx087 contributor: fullname: Nakayama – volume: 8 issue: 2 year: 2017 ident: 10.1016/j.pnpbp.2021.110255_bb0410 article-title: Primary cilia as a possible link between left-right asymmetry and neurodevelopmental diseases publication-title: Genes doi: 10.3390/genes8020048 contributor: fullname: Trulioff – volume: 11 issue: 8 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0420 article-title: Gefitinib, an EGFR tyrosine kinase inhibitor, prevents smoke-mediated ciliated airway epithelial cell loss and promotes their recovery publication-title: PLoS One doi: 10.1371/journal.pone.0160216 contributor: fullname: Valencia-Gattas – volume: 76 start-page: 1108 issue: 6 year: 2012 ident: 10.1016/j.pnpbp.2021.110255_bb0025 article-title: Tangentially migrating neurons assemble a primary cilium that promotes their reorientation to the cortical plate publication-title: Neuron doi: 10.1016/j.neuron.2012.10.027 contributor: fullname: Baudoin – volume: 450 start-page: 3 year: 2020 ident: 10.1016/j.pnpbp.2021.110255_bb0260 article-title: Mutations in ciliary trafficking genes affect sonic hedgehog-dependent neural tube patterning differentially along the anterior-posterior Axis publication-title: Neuroscience doi: 10.1016/j.neuroscience.2020.07.015 contributor: fullname: Legue – volume: 632 start-page: 130 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0380 article-title: A cis-eQTL in AHI1 confers risk to schizophrenia in European populations publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2016.08.050 contributor: fullname: Ren – volume: 98 start-page: 45 year: 2015 ident: 10.1016/j.pnpbp.2021.110255_bb0460 article-title: Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1) publication-title: Neurosci. Res. doi: 10.1016/j.neures.2015.02.002 contributor: fullname: Zoubovsky – volume: 63 start-page: 844 issue: 8 year: 2006 ident: 10.1016/j.pnpbp.2021.110255_bb0150 article-title: Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.63.8.844 contributor: fullname: Gurling – volume: 143 start-page: 1591 issue: 6 year: 1998 ident: 10.1016/j.pnpbp.2021.110255_bb0360 article-title: Distinct mutants of retrograde intraflagellar transport (IFT) share similar morphological and molecular defects publication-title: J. Cell Biol. doi: 10.1083/jcb.143.6.1591 contributor: fullname: Piperno – start-page: 9(6) year: 2017 ident: 10.1016/j.pnpbp.2021.110255_bb0070 article-title: Pedersen LB: primary cilia and coordination of receptor tyrosine kinase (rtk) and transforming growth factor beta (TGF-beta) signaling publication-title: Cold Spring Harb. Perspect. Biol. contributor: fullname: Christensen – volume: 11 start-page: 457 issue: 6 year: 2001 ident: 10.1016/j.pnpbp.2021.110255_bb0365 article-title: An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C-elegans ciliated sensory neurons publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00122-1 contributor: fullname: Qin – volume: 15 start-page: 988 issue: 9 year: 2007 ident: 10.1016/j.pnpbp.2021.110255_bb0205 article-title: Support for involvement of the AHI1 locus in schizophrenia publication-title: Eur. J. human genetics : EJHG doi: 10.1038/sj.ejhg.5201848 contributor: fullname: Ingason – volume: 19 start-page: 904 issue: 2 year: 2019 ident: 10.1016/j.pnpbp.2021.110255_bb0340 article-title: Personalized Nanotherapy by specifically targeting cell organelles to improve vascular hypertension publication-title: Nano Lett. doi: 10.1021/acs.nanolett.8b04138 contributor: fullname: Pala – volume: 18 start-page: 533 issue: 9 year: 2017 ident: 10.1016/j.pnpbp.2021.110255_bb0375 article-title: Genes and molecular pathways underpinning ciliopathies publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2017.60 contributor: fullname: Reiter – volume: 42 start-page: 703 issue: 5 year: 2004 ident: 10.1016/j.pnpbp.2021.110255_bb0415 article-title: Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons publication-title: Neuron doi: 10.1016/S0896-6273(04)00268-5 contributor: fullname: Tsujikawa – volume: 128 start-page: 1493 issue: 9 year: 2001 ident: 10.1016/j.pnpbp.2021.110255_bb0170 article-title: The C-elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms publication-title: Development doi: 10.1242/dev.128.9.1493 contributor: fullname: Haycraft – volume: 18 start-page: 1740 issue: 10 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0330 article-title: Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of hedgehog signaling publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp113 contributor: fullname: Norman – volume: 136 start-page: 278 issue: 4 year: 2012 ident: 10.1016/j.pnpbp.2021.110255_bb0395 article-title: Methylation and expression analyses of the 7q autism susceptibility locus genes MEST, COPG2, and TSGA14 in human and anthropoid primate cortices publication-title: Cytogenetic and genome research doi: 10.1159/000337298 contributor: fullname: Schneider – volume: 10 issue: 6 year: 2015 ident: 10.1016/j.pnpbp.2021.110255_bb0335 article-title: Identification of G protein-coupled receptors (GPCRs) in primary cilia and their possible involvement in body weight control publication-title: PLoS One doi: 10.1371/journal.pone.0128422 contributor: fullname: Omori – volume: 283 start-page: L1263 issue: 6 year: 2002 ident: 10.1016/j.pnpbp.2021.110255_bb0110 article-title: Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone publication-title: Am. J. Physiol. Lung Cell. Mol. Physiol. doi: 10.1152/ajplung.00180.2002 contributor: fullname: Evans – volume: 478 start-page: 483 issue: 7370 year: 2011 ident: 10.1016/j.pnpbp.2021.110255_bb0240 article-title: Spatio-temporal transcriptome of the human brain publication-title: Nature doi: 10.1038/nature10523 contributor: fullname: Kang – volume: 24 start-page: 2180 issue: 19 year: 2010 ident: 10.1016/j.pnpbp.2021.110255_bb0295 article-title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia publication-title: Genes Dev. doi: 10.1101/gad.1966210 contributor: fullname: Mukhopadhyay – volume: 195 start-page: 412 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0305 article-title: Primary cilia formation is diminished in schizophrenia and bipolar disorder: a possible marker for these psychiatric diseases publication-title: Schizophr. Res. doi: 10.1016/j.schres.2017.08.055 contributor: fullname: Munoz-Estrada – volume: 22 start-page: 762 issue: 4 year: 2012 ident: 10.1016/j.pnpbp.2021.110255_bb0385 article-title: The 5-HT(7) receptor in learning and memory publication-title: Hippocampus doi: 10.1002/hipo.20938 contributor: fullname: Roberts – volume: 128 start-page: 45 issue: 1 year: 2007 ident: 10.1016/j.pnpbp.2021.110255_bb0245 article-title: Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans publication-title: Cell doi: 10.1016/j.cell.2006.12.017 contributor: fullname: Keays – volume: 137 start-page: 32 issue: 1 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0140 article-title: The vertebrate primary cilium in development, homeostasis, and disease publication-title: Cell doi: 10.1016/j.cell.2009.03.023 contributor: fullname: Gerdes – volume: 89 start-page: 909 issue: 3 year: 1999 ident: 10.1016/j.pnpbp.2021.110255_bb0160 article-title: Selective targeting of somatostatin receptor 3 to neuronal cilia publication-title: Neuroscience doi: 10.1016/S0306-4522(98)00354-6 contributor: fullname: Handel – volume: 140 start-page: 74 issue: 1 year: 2010 ident: 10.1016/j.pnpbp.2021.110255_bb0405 article-title: Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance publication-title: Cell doi: 10.1016/j.cell.2009.12.011 contributor: fullname: Tischfield – volume: 93 start-page: 475 issue: 5 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0270 article-title: Primary cilia integrate hedgehog and Wnt signaling during tooth development publication-title: J. Dent. Res. doi: 10.1177/0022034514528211 contributor: fullname: Liu – volume: 18 start-page: 869 issue: 11 year: 2019 ident: 10.1016/j.pnpbp.2021.110255_bb0020 article-title: Adhesion G protein-coupled receptors: opportunities for drug discovery publication-title: Nat. Rev. Drug Discov. doi: 10.1038/s41573-019-0039-y contributor: fullname: Bassilana – volume: 41 start-page: 746 issue: 6 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0230 article-title: Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria publication-title: Nat. Genet. doi: 10.1038/ng.380 contributor: fullname: Jaglin – volume: 9 issue: 3 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0060 article-title: A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies publication-title: PLoS One doi: 10.1371/journal.pone.0090980 contributor: fullname: Chang – volume: 151 start-page: 709 issue: 3 year: 2000 ident: 10.1016/j.pnpbp.2021.110255_bb0355 article-title: Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene Tg737, are required for assembly of cilia and flagella publication-title: J. Cell Biol. doi: 10.1083/jcb.151.3.709 contributor: fullname: Pazour – volume: 11 start-page: 5903 issue: 1 year: 2020 ident: 10.1016/j.pnpbp.2021.110255_bb0290 article-title: PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia publication-title: Nat. Commun. doi: 10.1038/s41467-020-19637-5 contributor: fullname: Monroe TO – volume: 25 start-page: 555 issue: 12 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0225 article-title: Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects publication-title: Trends Genet. doi: 10.1016/j.tig.2009.10.003 contributor: fullname: Jaglin – volume: 17 start-page: 3887 issue: 24 year: 2008 ident: 10.1016/j.pnpbp.2021.110255_bb0005 article-title: Association of common variants in the Joubert syndrome gene (AHI1) with autism publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddn291 contributor: fullname: Alvarez Retuerto – volume: 589 start-page: 1607 issue: 14 year: 2015 ident: 10.1016/j.pnpbp.2021.110255_bb0195 article-title: Regulation of neuronal communication by G protein-coupled receptors publication-title: FEBS Lett. doi: 10.1016/j.febslet.2015.05.007 contributor: fullname: Huang – volume: 426 start-page: 83 issue: 6962 year: 2003 ident: 10.1016/j.pnpbp.2021.110255_bb0200 article-title: Hedgehog signalling in the mouse requires intraflagellar transport proteins publication-title: Nature doi: 10.1038/nature02061 contributor: fullname: Huangfu – volume: 156B start-page: 303 issue: 3 year: 2011 ident: 10.1016/j.pnpbp.2021.110255_bb0250 article-title: Mutations in the TSGA14 gene in families with autism spectrum disorders publication-title: Am. J. Med. Genet. B Neuropsychiatr. Genet. doi: 10.1002/ajmg.b.31162 contributor: fullname: Korvatska – volume: 153 start-page: 13 issue: 1 year: 2001 ident: 10.1016/j.pnpbp.2021.110255_bb0215 article-title: Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases publication-title: J. Cell Biol. doi: 10.1083/jcb.153.1.13 contributor: fullname: Iomini – volume: 1768 start-page: 976 issue: 4 year: 2007 ident: 10.1016/j.pnpbp.2021.110255_bb0055 article-title: G protein-coupled receptors in major psychiatric disorders publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamem.2006.09.025 contributor: fullname: Catapano – volume: 19 start-page: 1379 issue: 7 year: 2010 ident: 10.1016/j.pnpbp.2021.110255_bb0210 article-title: A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddq009 contributor: fullname: Ingason – start-page: 22(7) year: 2017 ident: 10.1016/j.pnpbp.2021.110255_bb0265 article-title: Role of G protein-coupled receptors in the regulation of structural plasticity and cognitive function publication-title: Molecules contributor: fullname: Leung – volume: 359 start-page: 693 issue: 6376 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0135 article-title: Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap publication-title: Science doi: 10.1126/science.aad6469 contributor: fullname: Gandal – volume: 16 start-page: 1099 issue: 9 year: 2015 ident: 10.1016/j.pnpbp.2021.110255_bb0400 article-title: Ins and outs of GPCR signaling in primary cilia publication-title: EMBO Rep. doi: 10.15252/embr.201540530 contributor: fullname: Schou – volume: 78 start-page: 311 issue: 3 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0165 article-title: Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes publication-title: Developmental Neurobiol. doi: 10.1002/dneu.22542 contributor: fullname: Hartwig – volume: 58 start-page: 955 issue: 12 year: 2005 ident: 10.1016/j.pnpbp.2021.110255_bb0180 article-title: Platelet adenylyl cyclase activity: a biological marker for major depression and recent drug use publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2005.05.040 contributor: fullname: Hines – volume: 14 start-page: 556 issue: 6 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0105 article-title: DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release publication-title: Mol. Psychiatry doi: 10.1038/mp.2009.13 contributor: fullname: Eastwood – volume: 2 start-page: 1554 issue: 6 year: 2012 ident: 10.1016/j.pnpbp.2021.110255_bb0050 article-title: Mutations in the beta-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities publication-title: Cell Rep. doi: 10.1016/j.celrep.2012.11.017 contributor: fullname: Breuss – volume: 15 start-page: 615 issue: 6 year: 2010 ident: 10.1016/j.pnpbp.2021.110255_bb0095 article-title: A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia publication-title: Mol. Psychiatry doi: 10.1038/mp.2008.128 contributor: fullname: Datta – volume: 17 start-page: 36 issue: 1 year: 2012 ident: 10.1016/j.pnpbp.2021.110255_bb0450 article-title: Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned publication-title: Mol. Psychiatry doi: 10.1038/mp.2010.109 contributor: fullname: Wray – volume: 24 start-page: 333 issue: 4 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0440 article-title: Neuronal cilia: another player in the Melanocortin system publication-title: Trends Mol. Med. doi: 10.1016/j.molmed.2018.02.004 contributor: fullname: Varela – volume: 3 start-page: 9 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0015 article-title: Remodeling Cildb, a popular database for cilia and links for ciliopathies publication-title: Cilia doi: 10.1186/2046-2530-3-9 contributor: fullname: Arnaiz – volume: 10 start-page: 27 issue: 1 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0425 article-title: Primary cilia in neurodevelopmental disorders publication-title: Nat. Rev. Neurol. doi: 10.1038/nrneurol.2013.247 contributor: fullname: Valente – year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0010 article-title: Cildb: a knowledgebase for centrosomes and cilia publication-title: Database doi: 10.1093/database/bap022 contributor: fullname: Arnaiz – volume: 19 start-page: 220 issue: 3 year: 2009 ident: 10.1016/j.pnpbp.2021.110255_bb0255 article-title: The primary cilium as a cellular signaling center: lessons from disease publication-title: Curr. Opin. Genet. Dev. doi: 10.1016/j.gde.2009.04.008 contributor: fullname: Lancaster – volume: 14 issue: 5 year: 2019 ident: 10.1016/j.pnpbp.2021.110255_bb0435 article-title: CiliaCarta: an integrated and validated compendium of ciliary genes publication-title: PLoS One doi: 10.1371/journal.pone.0216705 contributor: fullname: van Dam – volume: 540 start-page: 423 issue: 7633 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0350 article-title: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism publication-title: Nature doi: 10.1038/nature20612 contributor: fullname: Parikshak – volume: 9 issue: 10 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0445 article-title: Orphan G-protein coupled receptor 22 (Gpr22) regulates cilia length and structure in the zebrafish Kupffer’s vesicle publication-title: PLoS One doi: 10.1371/journal.pone.0110484 contributor: fullname: Verleyen – volume: 63 start-page: 844 issue: 8 year: 2006 ident: 10.1016/j.pnpbp.2021.110255_bb0155 article-title: Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.63.8.844 contributor: fullname: Gurling – volume: 94 start-page: 634 issue: 4 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0090 article-title: De novo mutations in the Beta-tubulin gene TUBB2A cause simplified Gyral patterning and infantile-onset epilepsy publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2014.03.009 contributor: fullname: Cushion – volume: 39 start-page: 84 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0175 article-title: The primary cilium as a cellular receiver: organizing ciliary GPCR signaling publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2016.02.008 contributor: fullname: Hilgendorf – volume: 65 start-page: 996 issue: 9 year: 2008 ident: 10.1016/j.pnpbp.2021.110255_bb0235 article-title: Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.65.9.996 contributor: fullname: Kamiya – volume: 80 start-page: 836 issue: 11 year: 2016 ident: 10.1016/j.pnpbp.2021.110255_bb0065 article-title: Ablation of type III adenylyl cyclase in mice causes reduced neuronal activity, altered sleep pattern, and depression-like phenotypes publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2015.12.012 contributor: fullname: Chen – start-page: 362(6420) year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0130 article-title: Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder publication-title: Science contributor: fullname: Gandal – volume: 300 start-page: 523 issue: 2 year: 2006 ident: 10.1016/j.pnpbp.2021.110255_bb0185 article-title: Hippi is essential for node cilia assembly and sonic hedgehog signaling publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2006.09.001 contributor: fullname: Houde – volume: 24 start-page: 2180 issue: 19 year: 2010 ident: 10.1016/j.pnpbp.2021.110255_bb0300 article-title: TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia publication-title: Genes Dev. doi: 10.1101/gad.1966210 contributor: fullname: Mukhopadhyay – volume: 11 start-page: 1591 issue: 20 year: 2001 ident: 10.1016/j.pnpbp.2021.110255_bb0045 article-title: The bld1 mutation identifies the Chlamydomonas osm-6 homolog as a gene required for flagellar assembly publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00485-7 contributor: fullname: Brazelton – volume: 110 start-page: 6943 issue: 17 year: 2013 ident: 10.1016/j.pnpbp.2021.110255_bb0430 article-title: Evolution of modular intraflagellar transport from a coatomer-like progenitor publication-title: P Natl Acad Sci USA doi: 10.1073/pnas.1221011110 contributor: fullname: van Dam – volume: 13 start-page: 3555 issue: 3 year: 2019 ident: 10.1016/j.pnpbp.2021.110255_bb0345 article-title: Ciliotherapy: remote control of primary cilia movement and function by magnetic nanoparticles publication-title: ACS Nano doi: 10.1021/acsnano.9b00033 contributor: fullname: Pala – volume: 9 issue: 6 year: 2014 ident: 10.1016/j.pnpbp.2021.110255_bb0370 article-title: Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia publication-title: PLoS One doi: 10.1371/journal.pone.0099892 contributor: fullname: Rampino – volume: 69 start-page: 1046 issue: 6 year: 2011 ident: 10.1016/j.pnpbp.2021.110255_bb0275 article-title: Cilia in the CNS: the quiet organelle claims center stage publication-title: Neuron doi: 10.1016/j.neuron.2011.03.002 contributor: fullname: Louvi – volume: 9 start-page: 152 issue: 1 year: 2019 ident: 10.1016/j.pnpbp.2021.110255_bb0145 article-title: Commonality in dysregulated expression of gene sets in cortical brains of individuals with autism, schizophrenia, and bipolar disorder publication-title: Transl. Psychiatry doi: 10.1038/s41398-019-0488-4 contributor: fullname: Guan – volume: 39 start-page: 727 issue: 6 year: 2007 ident: 10.1016/j.pnpbp.2021.110255_bb0030 article-title: IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy publication-title: Nat. Genet. doi: 10.1038/ng2038 contributor: fullname: Beales – volume: 61 start-page: 744 issue: 12 year: 2018 ident: 10.1016/j.pnpbp.2021.110255_bb0390 article-title: Tubulin genes and malformations of cortical development publication-title: Eur J Med Genet doi: 10.1016/j.ejmg.2018.07.012 contributor: fullname: Romaniello |
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| SubjectTerms | Autism Bipolar disorder Brain - metabolism Cilia Cilia - genetics Cilia - metabolism Compartments Databases, Genetic DEGs Depression Gene Expression Profiling Gene Expression Regulation Humans Mental Disorders - genetics Mental Disorders - metabolism Schizophrenia |
| Title | Patterns of cilia gene dysregulations in major psychiatric disorders |
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