Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes

Role for endogenous and acquired peroxidase in the toxoplasmacidal activity of murine and human mononuclear phagocytes

Toxoplasma gondii, eosinophil peroxidase (EPO) bound to parasite surface augments toxoplasmacidal activity of murine macrophages, monocytes from patients with myeloperoxidase deficiency have defect in toxoplasmacidal activity during early postphagocytic period which is reversed by presence of EPO on...

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Bibliographic Details
Published in:The Journal of clinical investigation Vol. 69; no. 5; pp. 1099 - 1111
Main Authors: Locksley, R.M, Wilson, C.B, Klebanoff, S.J
Format: Journal Article
Language:English
Published: United States 01-05-1982
Subjects:
Animals
eosinophils
Eosinophils - enzymology
Female
Humans
In Vitro Techniques
macrophages
Macrophages - immunology
Mice
Mice, Inbred BALB C
monocytes
Monocytes - immunology
Monocytes - metabolism
Oxygen Consumption
Peroxidases - immunology
Phagocytes - immunology
Phagocytes - metabolism
Resistance, Host
Toxoplasma - immunology
Toxoplasma gondii
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Description
Summary:Toxoplasma gondii, eosinophil peroxidase (EPO) bound to parasite surface augments toxoplasmacidal activity of murine macrophages, monocytes from patients with myeloperoxidase deficiency have defect in toxoplasmacidal activity during early postphagocytic period which is reversed by presence of EPO on surface of organism
ISSN:0021-9738
1558-8238
DOI:10.1172/jci110545