Carboplatin and oxaliplatin decomposition in chloride medium, monitored by XAS

The stability of carboplatin and oxaliplatin aqueous solutions has been studied under different chloride ions concentration and pH conditions. For both compounds, we demonstrate the chloration of the platinum first coordination shell.

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Bibliographic Details
Published in:	Journal of synchrotron radiation Vol. 8; no. Pt 2; p. 716
Main Authors:	Curis, E, Provost, K, Bouvet, D, Nicolis, I, Crauste-Manciet, S, Brossard, D, Bénazeth, S
Format:	Journal Article
Language:	English
Published:	United States 01-03-2001
Subjects:	Antineoplastic Agents - chemistry Carboplatin - chemistry Chlorides - chemistry Cisplatin - chemistry Drug Stability Fourier Analysis Hydrogen-Ion Concentration Organoplatinum Compounds - chemistry Oxaliplatin Solutions Spectrometry, X-Ray Emission - methods
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Description
Summary:	The stability of carboplatin and oxaliplatin aqueous solutions has been studied under different chloride ions concentration and pH conditions. For both compounds, we demonstrate the chloration of the platinum first coordination shell.
ISSN:	0909-0495
DOI:	10.1107/S0909049500017775