Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

• Published in: Tetrahedron Vol. 65; no. 50; pp. 10424 - 10429
• Main Authors: Festa, Carmen, De Marino, Simona, Sepe, Valentina, Monti, Maria Chiara, Luciano, Paolo, D'Auria, Maria Valeria, Débitus, Cecile, Bucci, Mariarosaria, Vellecco, Valentina, Zampella, Angela
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 12-12-2009; Elsevier
• Subjects: Biochemistry, Molecular Biology; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chemistry; Exact sciences and technology; General pharmacology; Life Sciences; Marine; Medical sciences; Organic chemistry; Peptides; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Preparations and properties; Theonella swinhoei; Melanesia; Oceania; Solomon Islands; Molecular structure; Metabolite; Cyclic peptides; Pharmacognosy; Antiinflammatory agent; Animal origin; NMR spectrometry; Biological activity; Electrospray; Marine environment; In vivo; Porifera; Isolation; Sponge; Invertebrata; Mass spectrometry; Structural analysis
• ISSN: 0040-4020; 1464-5416
• DOI: 10.1016/j.tet.2009.10.026

Two new metabolites, perthamides C and D, have been isolated from the marine sponge
Theonella swinhoei. Their structures were determined by interpretation of NMR and ESIMS data. All compounds exhibited in vivo potent anti-inflammatory activity. Biological activity and structural elucidation are reported.
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