Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-κB Signaling in MDA-MB-231 Cells

Breast cancer (BC) a very common cancer in women worldwide. Triple negative breast cancer (TNBC) has been shown to have a poor prognosis with a high level of tumor metastatic spread. Here, the inhibitory effects of ginsenoside-Rh1 (Rh1) on BC metastasis, and its underlying signaling pathway in TNBC...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 19; p. 10458
Main Authors:	Jin, Yujin, Huynh, Diem Thi Ngoc, Myung, Chang-Seon, Heo, Kyung-Sun
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-10-2021 MDPI
Subjects:	Angiogenesis Apoptosis Breast cancer Cell adhesion & migration Cytokines Gelatinase A Gelatinase B ginsenoside Rh1 Inflammation Kinases Liver cancer Metastases Metastasis Mitochondria mitochondrial ROS Morphology Mutation NF-κB NF-κB protein Phosphorylation Protein expression Proteins Signal transduction STAT3 Stat3 protein Transcription triple-negative breast cancer cells Tumorigenesis Vascular endothelial growth factor Western blotting Wound healing
Online Access:	Get full text
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