Analysis and Sequence Alignment of Peste des Petits Ruminants Virus ChinaSX2020

• Published in: Veterinary sciences Vol. 8; no. 11; p. 285
• Main Authors: Li, Lingxia, Wu, Jinyan, Cao, Xiaoan, He, Jijun, Liu, Xiangtao, Shang, Youjun
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22-11-2021; MDPI
• Subjects: Brief Report; ChinaSX2020; Epidemics; Gene amplification; genome; Genomes; Genotypes; Immunization; Immunofluorescence; Infections; Laboratories; Lymphatic system; Nucleotide sequence; Nucleotides; Peste des petits ruminants; Phylogenetics; Phylogeny; PPRV; sequence alignment; Serology; Sheep; Small intestine; Spleen; Vaccines; United States > US; China
• ISSN: 2306-7381; 2306-7381
• DOI: 10.3390/vetsci8110285

The peste des petits ruminants virus (PPRV) mainly infects goats and sheep and causes a highly contagious disease, PPR. Recently, a PPRV strain named ChinaSX2020 was isolated and confirmed following an indirect immunofluorescence assay and PCR using PPRV-specific antibody and primers, respectively. A sequencing of the ChinaSX2020 strain showed a genome length of 15,954 nucleotides. A phylogenetic tree analysis showed that the ChinaSX2020 genome was classified into lineage IV of the PRRV genotypes. The genome of the ChinaSX2020 strain was found to be closely related to PPRVs isolated in China between 2013 and 2014. These findings revealed that not a variety of PRRVs but similar PPRVs were continuously spreading and causing sporadic outbreaks in China.