Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2–Nf-kb Pathway Alterations

• Published in: International journal of molecular sciences Vol. 23; no. 19; p. 11320
• Main Authors: D’Amico, Ramona, Di Paola, Davide, Impellizzeri, Daniela, Genovese, Tiziana, Fusco, Roberta, Peritore, Alessio Filippo, Gugliandolo, Enrico, Crupi, Rosalia, Interdonato, Livia, Cuzzocrea, Salvatore, Di Paola, Rosanna, Siracusa, Rosalba, Cordaro, Marika
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-10-2022; MDPI
• Subjects: Animal health; Animals; Apoptosis; Chronic exposure; Collagen; Cytokines; Dicarboximide; Disease; Disruption; DNA damage; endocrine disruptor; Endocrine disruptors; Environmental protection; Exposure; Fruits; Fungicides; Inflammation; Lipid peroxidation; Lipids; lung injury; Lungs; Metabolites; NF-κB protein; Oral administration; Organs; Oxidative stress; Pesticides; Physiology; Reproductive system; Sperm; Vinclozolin; United States > US
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms231911320

Endocrine-disrupting substances (EDS) are common and pervasive in our environment and pose a serious risk to both human and animal health. Endocrine-disrupting compounds (EDCs) have been associated with a variety of detrimental human health effects, including respiratory issues, as a result of their ability to disrupt cell physiology. Vinclozolin ((RS)-3-(3,5-Dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione) is a common dicarboximide fungicide used to treat plant diseases. Several studies have analyzed the effects of vinclozolin exposure on the reproductive system, but less is known about its effect on other organs such as the lung. Mice were exposed for 28 days to orally administered vinclozolin at a dose of 100 mg/kg. Vinclozolin exposure induced histological alterations and collagen depositions in the lung. Additionally, vinclozolin induced inflammation and oxidative stress that led to lung apoptosis. Our study demonstrates for the first time that the toxicological effects of vinclozolin are not limited to the reproductive system but also involve other organs such as the lung.