Primary mFOLFOX6 Plus Bevacizumab Without Resection of the Primary Tumor for Patients Presenting With Surgically Unresectable Metastatic Colon Cancer and an Intact Asymptomatic Colon Cancer: Definitive Analysis of NSABP Trial C-10

Major concerns surround combining chemotherapy with bevacizumab in patients with colon cancer presenting with an asymptomatic intact primary tumor (IPT) and synchronous yet unresectable metastatic disease. Surgical resection of asymptomatic IPT is controversial. Eligibility for this prospective, mul...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 30; no. 26; pp. 3223 - 3228
Main Authors:	MCCAHILL, Laurence E, YOTHERS, Greg, WAGMAN, Lawrence D, O'CONNELL, Michael J, WOLMARK, Norman, SHARIF, Saima, PETRELLI, Nicholas J, LAI, Lily Lau, BECHAR, Naftali, GIGUERE, Jeffrey K, DAKHIL, Shaker R, FEHRENBACHER, Louis, LOPA, Samia H
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Society of Clinical Oncology 10-09-2012
Subjects:	Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Biological and medical sciences Colonic Neoplasms - drug therapy Colonic Neoplasms - mortality Colonic Neoplasms - pathology Female Fluorouracil - adverse effects Fluorouracil - therapeutic use Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Hemorrhage - epidemiology Humans Intestinal Obstruction - epidemiology Intestinal Perforation - epidemiology Leucovorin - adverse effects Leucovorin - therapeutic use Male Medical sciences Middle Aged Neoplasm Metastasis - drug therapy Organoplatinum Compounds - adverse effects Organoplatinum Compounds - therapeutic use Original Reports Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Antineoplastic agent Human Surgical resection Asymptomatic Monoclonal antibody Malignant tumor Metastasis Bevacizumab Colonic disease Colon cancer Cancerology Vascular endothelium growth factor Treatment Surgery Primary Unresectable Digestive diseases Intestinal disease Clinical trial Advanced stage Antiangiogenic agent Cancer
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