Rapid thymectomy of NSG mice to analyze the role of native and grafted thymi in humanized mice

We developed a rapid method to remove the native mouse thymus from NSG mice, which allowed us to compare the behavior of human immune cells in the presence or absence of human T cells in human immune system mice. Removing the native mouse thymus is critical for studies of human thymopiesis in grafte...

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Bibliographic Details
Published in:	European journal of immunology Vol. 50; no. 1; pp. 138 - 141
Main Authors:	Khosravi‐Maharlooei, Mohsen, Hoelzl, Markus, Li, Hao Wei, Madley, Rachel C., Waffarn, Elizabeth E., Danzl, Nichole M., Sykes, Megan
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-01-2020
Subjects:	Animal tissues Animals Hematopoietic stem cells Human behavior Humanized mice Humans Immune system Lymphocytes Lymphocytes T Mice Mice, Inbred NOD Mice, SCID NSG mice Thymectomy Thymectomy - methods Thymopoiesis Thymus Thymus Gland - immunology Thymus Gland - transplantation Transplantation, Heterologous - methods Thymopoiesis NSG mice Thymectomy Humanized mice Hematopoietic stem cells
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