Single‐chain factor XII exhibits activity when complexed to polyphosphate

Summary Background The mechanism underpinning factor XII autoactivation was originally characterized with non‐physiological surfaces, such as dextran sulfate (DS), ellagic acid, and kaolin. Several ‘natural’ anionic activating surfaces, such as platelet polyphosphate (polyP), have now been identifie...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 12; no. 9; pp. 1513 - 1522
Main Authors:	Engel, R., Brain, C. M., Paget, J., Lionikiene, A. S., Mutch, N. J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01-09-2014
Subjects:	Amino Acid Chloromethyl Ketones - chemistry Anions - chemistry Arginine - chemistry blood coagulation Blood Platelets - metabolism Catalytic Domain Dextran Sulfate - chemistry Disulfides - chemistry Ellagic Acid - chemistry Enzyme Precursors - chemistry Factor XII - chemistry factor XII Hemostasis Humans Kaolin - chemistry Plant Proteins - chemistry polyphosphates Polyphosphates - chemistry Prekallikrein - chemistry Protein Binding RNA - chemistry Surface Properties zymogens zymogens hemostasis blood coagulation factor XII polyphosphates
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