SUBCHRONIC EFFECTS FOLLOWING A SINGLE SARIN EXPOSURE ON BLOOD-BRAIN AND BLOOD-TESTES BARRIER PERMEABILITY, ACETYLCHOLINESTERASE, AND ACETYLCHOLINE RECEPTORS IN THE CENTRAL NERVOUS SYSTEM OF RAT: A DOSE-RESPONSE STUDY

Subchronic neurotoxic effects of sarin (O-isopropyl methylphosphonofluoridate) treatment at various doses in male Sprague Dawley rats were studied. The animals were treated with a single intramuscular (im) injection of 0.01, 0.1, 0.5, or 1 x LD50 (100 microg/kg). The animals were maintained for 90 d...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of Toxicology and Environmental Health, Part A Vol. 61; no. 8; pp. 695 - 707
Main Authors:	Jones, Katherine H., Dechkovskaia, Anjelika M., Herrick, Elizabeth A., Abdel-Rahman, Ali A., Khan, Wasiuddin A., Abou-Donia, Mohamed B.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 29-12-2000
Subjects:	Acetylcholinesterase - analysis Acetylcholinesterase - drug effects Animals Binding Sites Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Blood-Testis Barrier - drug effects Blood-Testis Barrier - physiology Central Nervous System - metabolism Chemical Warfare Agents - pharmacokinetics Chemical Warfare Agents - toxicity Dose-Response Relationship, Drug Lethal Dose 50 Ligands Male Permeability Persian Gulf Syndrome - etiology Rats Rats, Sprague-Dawley Receptors, Cholinergic - analysis Receptors, Cholinergic - drug effects Sarin - pharmacokinetics Sarin - toxicity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!