Synthesis and Evaluation of Antimicrobial Activity of the Rearranged Abietane Prattinin A and Its Synthetic Derivatives

Synthesis of the natural product prattinin A and some new derivatives has been achieved using abietic acid. The final products and a selection of intermediates were evaluated for their antibacterial activity against three human pathogenic bacteria: , , and . The results showed that the antibacterial...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 29; no. 3; p. 650
Main Authors:	Ait El Had, Mustapha, Zefzoufi, Manal, Zentar, Houda, Bahsis, Lahoucine, Hachim, Mouhi Eddine, Ghaleb, Adib, Khelifa-Mahdjoubi, Choukri, Bouamama, Hafida, Alvarez-Manzaneda, Ramón, Justicia, José, Chahboun, Rachid
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-01-2024
Subjects:	abietane rearranged ADMET antibacterial activity Antibiotics Antimicrobial agents Bacteria Ciprofloxacin Crystals DFT calculation Escherichia coli Metabolites natural product Natural products Oxidation Phenols prattinin A Staphylococcus aureus Staphylococcus infections Structure antibacterial activity DFT calculation prattinin A molecular docking abietane rearranged natural product ADMET
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