Pain reactivity and recovery in preterm neonates: latency, magnitude, and duration of behavioral responses

• Published in: Early human development Vol. 85; no. 5; pp. 313 - 318
• Main Authors: Chimello, Juliana Thomazatti, Gaspardo, Cláudia Maria, Cugler, Thaís Souza, Martinez, Francisco Eulógio, Linhares, Maria Beatriz Martins
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01-05-2009; Elsevier
• Subjects: Advanced Basic Science; Biological and medical sciences; Blood Specimen Collection - adverse effects; Cross-Sectional Studies; Embryology: invertebrates and vertebrates. Teratology; Facial Expression; Fundamental and applied biological sciences. Psychology; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Neonatal and Perinatal Medicine; NICU; Pain; Pain - diagnosis; Pain - physiopathology; Pain Measurement - methods; Preterm; Reactivity; Recovery; Sleep - physiology; NICU; Pain; Reactivity; Recovery; Preterm; Human; Premature; Prematurity; Duration; Behavior
• ISSN: 0378-3782; 1872-6232
• DOI: 10.1016/j.earlhumdev.2008.12.005

Abstract Background Studies on acute-procedural pain in neonates have been based more on single behavioral scores than on response patterns. Aim To assess the individual reactivity and recovery pattern to the painful procedure of blood collection. Study design A cross-sectional, within-group comparison trial. Subjects Forty-eight preterm and very low birth weight neonates hospitalized in a Neonatal Intensive Care Unit. Outcome measures The assessment was divided into five consecutive phases: Baseline (BL); Antisepsis (A), covering the period of handling of the neonate for antisepsis prior to puncture; Puncture (P); Recovery-Dressing (RD), covering the period of handling of the neonate for dressing until positioning for rest in the isolette; and Recovery-Resting (RR). Facial activity was recorded by video, and sleep–wake state was recorded at the bedside. The facial activity of the neonates was analyzed according to Neonatal Facial Coding System (NFCS). The pain reactivity pattern was analyzed using the measures of latency, magnitude, and duration of behavioral responses and by comparison between the different phases. Results In the Antisepsis phase, the neonates showed higher NFCS score and behavioral arousal than at Baseline. In the Puncture phase, the neonates showed higher NFCS score and behavioral activation than in Baseline and in Antisepsis. In Recovery-Dressing, 31% of neonates continued to show more behavioral activation than at Baseline. Conclusion To better assess and manage pain in preterm neonates, it is relevant to analyze the individual patterns of changes, focusing on the reactivity and also the recovery, during painful stimuli.