In vitro activity of voriconazole, itraconazole, caspofungin, anidulafungin (VER002, LY303366) and amphotericin B against aspergillus spp

• Published in: Diagnostic microbiology and infectious disease Vol. 45; no. 2; pp. 131 - 135
• Main Authors: del Carmen Serrano, María, Valverde-Conde, Anastasio, Chávez, M.ónica, Bernal, Samuel, Claro, Rosa María, Pemán, Javier, Ramirez, Mercedes, Martín-Mazuelos, Estrella
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-02-2003; Elsevier
• Subjects: Amphotericin B - pharmacology; Anidulafungin; Anti-Bacterial Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - pharmacology; Aspergillosis - drug therapy; Aspergillosis - microbiology; Aspergillus - classification; Aspergillus - drug effects; Aspergillus - genetics; Biological and medical sciences; Caspofungin; Echinocandins; Humans; Itraconazole - pharmacology; Lipopeptides; Medical sciences; Microbial Sensitivity Tests; Peptides; Peptides, Cyclic - pharmacology; Pharmacology. Drug treatments; Pyrimidines - pharmacology; Time Factors; Triazoles - pharmacology; Voriconazole; Anidulafungin; In vitro; Biological activity; Fungi; Aspergillus; Antibiotic; Antifungal agent; Amphotericin B; Polyenic compound; Caspofungin; Voriconazole; Triazole derivatives; Fungi Imperfecti; Thallophyta; Itraconazole
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/S0732-8893(02)00507-2

Voriconazole, anidulafungin (VER002, LY303366) and caspofungin are promising antifungal agents which provide a good protection against a variety of fungi, including yeasts and filamentous fungi. In this study, we tested the in vitro efficacy of voriconazole, itraconazole, caspofungin, anidulafungin (VER002, LY303366) and amphotericin B, against different species of
Aspergillus spp. isolated from clinical specimens, using a microdilution broth method and following the NCCLS guidelines (document M38-P). We also evaluated the effect that time readings have on MIC results. For caspofungin, we determined the minimun effective concentration (MEC), defined like the lowest concentration of caspofungin causing abnormal hyphal growth. Anidulafungin (VER002, LY303366) was the most active antifungal agent tested with MIC
90 of ≤0,03 mg/L. The activity of voriconazole, and itraconazole very similar with MIC
90 of 0,12 mg/L, 0,12 mg/L respectively. For caspofungin the MEC
90 was of 0,25 mg/L. Amphotericin B was the lest active antifungal agent studied with MIC
90 of 1 mg/L. There were no differences between MIC values at 48 and 72 h. These data demonstrate promising activity of voriconazole, anidulafungin (VER002, LY303366) and caspofungin against
Apergillus spp.