Structure-based drug design: From nucleic acid to membrane protein targets

The in silico methods for drug discovery are becoming increasingly powerful and useful. That, in combination with increasing computer processor power, in our case using a novel distributed computing grid, has enabled us to greatly enhance our virtual screening efforts. Herein we review some of these...

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Bibliographic Details
Published in:	Experimental and molecular pathology Vol. 86; no. 3; pp. 141 - 150
Main Authors:	Dailey, Magdalena M., Hait, Chayanendu, Holt, Patrick A., Maguire, Jon M., Meier, Jason B., Miller, M. Clarke, Petraccone, Luigi, Trent, John O.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-06-2009
Subjects:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Computer Simulation DNA Drug Design Drug discovery Drug Discovery - methods Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - statistics & numerical data Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology G-protein coupled receptor Humans In Vitro Techniques Macrophage Migration-Inhibitory Factors - antagonists & inhibitors Macrophage Migration-Inhibitory Factors - chemistry Membrane protein Membrane Proteins - chemistry Membrane Proteins - drug effects Models, Molecular Molecular Structure Nucleic Acids - chemistry Nucleic Acids - drug effects Nucleolin Phosphofructokinase-2 - antagonists & inhibitors Phosphofructokinase-2 - chemistry Phosphoproteins - chemistry Phosphoproteins - drug effects Quadruplex Receptors, CXCR4 - chemistry Receptors, CXCR4 - drug effects RNA-Binding Proteins - chemistry RNA-Binding Proteins - drug effects Telomerase - antagonists & inhibitors Telomerase - chemistry Telomere User-Computer Interface Virtual screening Membrane protein PFKFB3 ADME Virtual screening MIF Quadruplex Telomere G-protein coupled receptor EMSA DNA rmsd GPCR Drug discovery
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