Aromatase and COX-2 expression in human breast cancers

We have investigated aromatase and the inducible cyclooxygenase COX-2 expression using immunocytochemistry in tumors of a series of patients with advanced breast cancer treated with aromatase inhibitors. Aromatase was expressed in 58/102 breast cancers. This is similar to the percentage previously r...

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Bibliographic Details
Published in:	Journal of steroid biochemistry and molecular biology Vol. 79; no. 1; pp. 41 - 47
Main Authors:	Brodie, A.M.H, Lu, Q, Long, B.J, Fulton, A, Chen, T, Macpherson, N, DeJong, P.C, Blankenstein, M.A, Nortier, J.W.R, Slee, P.H.T.J, van de Ven, J, van Gorp, J.M.H.H, Elbers, J.R.J, Schipper, M.E.I, Blijham, G.H, Thijssen, J.H
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Oxford Elsevier Ltd 01-12-2001 Elsevier Science
Subjects:	Adipocytes - enzymology Adult Aged Aged, 80 and over Animals Aromatase Aromatase - metabolism Aromatase Inhibitors Biological and medical sciences Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - pathology COX-2 Cyclooxygenase 2 Dinoprostone - metabolism Endothelium - enzymology Enzyme Inhibitors - therapeutic use Epithelial Cells - enzymology Estrogen Receptor Modulators - therapeutic use Estrogens - biosynthesis Female Humans Immunohistochemistry Isoenzymes - metabolism Letrozole Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - enzymology Mammary Neoplasms, Experimental - pathology Membrane Proteins Mice Mice, Inbred BALB C Middle Aged Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - enzymology Nitriles - therapeutic use Prostaglandin-Endoperoxide Synthases - metabolism Stromal Cells - enzymology Tamoxifen - therapeutic use Triazoles - therapeutic use Immunohistochemistry COX-2 Aromatase
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