Trichothecene Mycotoxins from Fusarium culmorum Cultures

• Published in: Zeitschrift für Naturforschung C. A journal of biosciences Vol. 42; no. 9; pp. 1043 - 1049
• Main Authors: Bycroft, Barrie W., Baldwin, Nigel C. P., Dewick, Paul M., Marsh, David C., Gilbert, John
• Format: Journal Article
• Language: English
• Published: Germany Verlag der Zeitschrift für Naturforschung 01-10-1987
• Subjects: Culture Media; Deoxynivalenol; Fusarium; Fusarium - growth & development; Magnetic Resonance Spectroscopy - methods; Mycotoxin; Mycotoxins - isolation & purification; Sesquiterpenes - isolation & purification; Structure-Activity Relationship; Trichothecene; Trichothecenes - isolation & purification
• ISSN: 0939-5075; 1865-7125
• DOI: 10.1515/znc-1987-9-1007

Chemical analysis of the culture filtrates of Fusarium culmorum CMI 14764 has demonstrated the presence of seven trichothecene mycotoxins. Major metabolites are 3-acetyldeoxynivalenol and 7α,8α-dihydroxycalonectrin. with 3,15-diacetyldeoxynivalenol, deoxynivalenol. calonectrin, isotrichodermin and 12,13-epoxytrichothec-9-ene (EPT) as minor products. The occurrence of the rarely encountered unsubstituted trichothecene EPT is significant in that this compound may function as a common intermediate in the biosynthetic pathways to all natural trichothecenes. The structures of the known trichothecenes isolated from F. culmorum suggest a route in which EPT is sequentially oxygenated to the more complex deoxynivalenol derivatives.