Differential Osteopontin Expression in Phenotypically Distinct Subclones of Murine Breast Cancer Cells Mediates Metastatic Behavior

Cancer progression depends on an accumulation of metastasis-supporting cell signaling molecules, which target signal transduction pathways and, ultimately, gene expression. One such molecule, osteopontin (OPN), represents a key molecular signaling event in tumor progression and metastasis. However,...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 279; no. 45; pp. 46659 - 46667
Main Authors:	Mi, Zhiyong, Guo, Hongtao, Wai, Philip Y, Gao, Chengjiang, Wei, Junping, Kuo, Paul C
Format:	Journal Article
Language:	English
Published:	United States American Society for Biochemistry and Molecular Biology 05-11-2004
Subjects:	Animals Binding Sites Biotin - pharmacology Blotting, Northern Blotting, Western Cell Adhesion Cell Line, Tumor Cell Movement Cell Nucleus - metabolism Dimerization DNA Mutational Analysis Humans Immunoblotting JNK Mitogen-Activated Protein Kinases - metabolism Luciferases - metabolism Mammary Neoplasms, Animal - metabolism Mice Mice, Inbred BALB C Mice, Inbred C3H Mutation Neoplasm Invasiveness Neoplasm Metastasis Osteopontin Phenotype Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Promoter Regions, Genetic RNA, Messenger - metabolism Sialoglycoproteins - biosynthesis Signal Transduction Streptavidin - pharmacology Transcription Factor AP-1 - metabolism Transcription, Genetic Transfection Up-Regulation
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