Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review w...

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Bibliographic Details
Published in:	Journal of Dental Research Vol. 88; no. 10; pp. 894 - 903
Main Authors:	Grundmann, O., Mitchell, G.C., Limesand, K.H.
Format:	Book Review Journal Article
Language:	English
Published:	United States SAGE Publications 01-10-2009
Subjects:	Animals Apoptosis - radiation effects Critical Reviews in Oral Biology & Medicine Disease Models, Animal Head and Neck Neoplasms - radiotherapy Humans Radiation Injuries - etiology Radiation Injuries - therapy Radiation Tolerance - physiology Radiation-Protective Agents - therapeutic use Radiotherapy - adverse effects Radiotherapy Dosage Salivary Gland Diseases - etiology Salivary Gland Diseases - therapy Salivary Glands - radiation effects Signal Transduction - radiation effects salivary glands animal models xerostomia radiation therapy salivary gland dysfunction
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Summary:	Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.
Bibliography:	authors contributing equally
ISSN:	0022-0345 1544-0591
DOI:	10.1177/0022034509343143