Unusual abdominal findings of all- trans -retinoic acid syndrome: role of diagnostic imaging

• Published in: Clinical imaging Vol. 31; no. 4; pp. 276 - 278
• Main Authors: La Fianza, Alfredo, Bonfichi, Maurizio, Gorone, Maria Sole Prevedoni, Gallotti, Anna, Torretta, Lorella
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-07-2007; Elsevier; Elsevier Limited
• Subjects: Abdomen - diagnostic imaging; Abdomen - pathology; Acute Disease; Acute promyelocytic leukemia (APL); Adult; ATRA syndrome; Biological and medical sciences; Diagnostic imaging; Fatal Outcome; Hematologic and hematopoietic diseases; Humans; Leukemia, Promyelocytic, Acute - complications; Leukemia, Promyelocytic, Acute - drug therapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Radiology; Retinoic acid syndrome (RAS); Syndrome; Tretinoin - adverse effects; Tretinoin - therapeutic use; Ultrasonography; Retinoic acid syndrome (RAS); Diagnostic imaging; Acute promyelocytic leukemia (APL); ATRA syndrome; Antineoplastic agent; Promyelocytic leukemia; Acute; Retinoid; Acute leukemia; Malignant hemopathy; Abdomen; Diagnosis; Retinoic acid; Tretinoin
• ISSN: 0899-7071; 1873-4499
• DOI: 10.1016/j.clinimag.2006.11.004

Abstract The standard therapy for patients affected by acute promyelocytic leukemia is based on all- trans -retinoic acid (ATRA), whose rare complication is a syndrome known as retinoic acid syndrome. We describe for the first time the computed tomography findings of a case of ATRA syndrome with typical pulmonary findings, along with the involvement of the upper abdomen organs (liver and spleen) as a further complication of the pathology.