Enhanced cellular accumulation of a P-glycoprotein substrate, rhodamine-123, by caco-2 cells using low molecular weight methoxypolyethylene glycol- block-polycaprolactone diblock copolymers

A series of diblock copolymers based on methoxypolyethylene glycol-block-poly(caprolactone) (MePEG- b-PCL) was synthesized and evaluated for enhancing the cellular accumulation of a P-glycoprotein (P-gp) substrate, rhodamine-123 (R-123), into caco-2 cells. Altering MePEG:caprolactone feed weight rat...

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Bibliographic Details
Published in:	European journal of pharmaceutics and biopharmaceutics Vol. 54; no. 3; pp. 299 - 309
Main Authors:	Zastre, Jason, Jackson, John, Bajwa, Mandeep, Liggins, Richard, Iqbal, Famida, Burt, Helen
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-11-2002 Elsevier Science
Subjects:	ATP-Binding Cassette, Sub-Family B, Member 1 - administration & dosage ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry ATP-Binding Cassette, Sub-Family B, Member 1 - pharmacokinetics Biological and medical sciences Caco-2 Cells Critical micelle concentration Diblock copolymers Drug Delivery Systems - methods General pharmacology Humans Medical sciences Micelles P-glycoprotein Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyesters - administration & dosage Polyesters - chemistry Polyesters - pharmacokinetics Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Rhodamine 123 - administration & dosage Rhodamine 123 - chemistry Rhodamine 123 - pharmacokinetics P-glycoprotein Critical micelle concentration Diblock copolymers Micelles Human Intracellular transport Pharmaceutical technology Targeting Digestive system Controlled release form Control release polymer Biological transport P Glycoprotein Micelle Drug carrier Ethylene oxide copolymer In vitro Caprolactone copolymer Established cell line Dosage form Chemical synthesis Molecular mass
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