Mucosal dendritic cells in allergy and immunotherapy

• Published in: Allergy (Copenhagen) Vol. 66; no. s95; pp. 22 - 24
• Main Authors: Novak, N., Allam, J.‐P.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-07-2011; Blackwell
• Subjects: Adjuvants; Allergen uptake; Allergens; Allergens - immunology; Allergies; Biological and medical sciences; CD14 antigen; Cells; Cytokines - biosynthesis; Cytokines - immunology; Dendritic cells; Dendritic Cells - immunology; Dermatology; Epithelium; Fc receptors; Fundamental and applied biological sciences. Psychology; Fundamental immunology; high‐affinity IgE receptor; Humans; Hypersensitivity; Hypersensitivity - immunology; Hypersensitivity - therapy; Immune system; Immune Tolerance - immunology; Immunotherapy; Langerhans cells; Langerhans Cells - immunology; Lipopolysaccharides; Medical sciences; Mouth Mucosa - cytology; Mouth Mucosa - immunology; Mucosa; Mucous membrane; Oral administration; oral mucosa; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; T-Lymphocytes, Regulatory - immunology; TLR4 protein; tolerance induction; Toll-like receptors; Allergy; Dendritic cell; Immunopathology; langerhans cells; Dermatology; oral mucosa; IgE; Mucosa; Oral administration; tolerance induction; Cell immunotherapy; high-affinity IgE receptor; Immunology; Langerhans cell; Antigen presenting cell; Immune tolerance; Allergen uptake; Affinity; Allergen; Biological receptor
• ISSN: 0105-4538; 1398-9995
• DOI: 10.1111/j.1398-9995.2011.02626.x

To cite this article: Novak N, Allam J‐P. Mucosal dendritic cells in allergy and immunotherapy. Allergy 2011; 66 (Suppl. 95): 22–24.
The oral epithelium contains oral mucosal Langerhans cells (oLCs) that constitutively express the high‐affinity IgE‐receptor FcεRI, the lipopolysaccharide receptor CD14 and toll‐like receptor (TLR)4. The distribution of oLCs profoundly differs at distinct oral mucosal sites, with higher numbers of oLCs detectable in the vestibulum compared with the sublingual region. The oLC response to activation of TLR4 and FcεRI and to binding of allergen suggests that these cells are involved in the maintenance of tolerance towards bacterial components and allergens. Thus, oLCs are important targets for allergens and adjuvants during sublingual immunotherapy, and characterizing them is crucial for improving allergen‐specific immunotherapy.