Acute Radiation Effects, the H-ARS in the Non-human Primate: A Review and New Data for the Cynomolgus Macaque with Reference to the Rhesus Macaque

Medical countermeasure development under the US Food and Drug Administration animal rule requires validated animal models of acute radiation effects. The key large animal model is the non-human primate, rhesus macaque. To date, only the rhesus macaque has been used for both critical supportive data...

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Bibliographic Details
Published in:	Health physics (1958) Vol. 121; no. 4; pp. 304 - 330
Main Authors:	Farese, Ann M., Drouet, Michel, Herodin, Francis, Bertho, Jean-Marc, Thrall, Karla D., Authier, Simon, Doyle-Eisele, Melanie, MacVittie, Thomas J.
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins 01-10-2021 Lippincott Williams & Wilkins Ovid Technologies Lippincott, Williams & Wilkins
Subjects:	Acute Radiation Syndrome - etiology Acute Radiation Syndrome - prevention & control Animal biology Animal models Animals Bone marrow Drug dosages Effectiveness Female Irradiation Life Sciences Macaca fascicularis Macaca mulatta Male Males Medical Countermeasures Myelosuppression Primates Radiation Radiation dosage Radiation effects Radiation Exposure - adverse effects Vaccine development Vaccines United States > US
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