Prophylaxis of lipopolysaccharide-induced shock by α-galactosylceramide

The NKT cell ligand α‐galactosylceramide and its synthetic homologue KRN7000 stimulate rapid and copious secretion of IFN‐γ and TNF‐α release, both of which are key mediators of LPS‐induced shock. We showed that KRN7000, injected before or within 2 h after LPS challenge, was able to prevent endotoxi...

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Bibliographic Details

Published in:	Journal of leukocyte biology Vol. 84; no. 2; pp. 550 - 560
Main Authors:	Sireci, Guido, La Manna, Marco Pio, Di Liberto, Diana, Lo Dico, Marco, Taniguchi, Masaru, Dieli, Francesco, Salerno, Alfredo
Format:	Journal Article
Language:	English
Published:	United States Society for Leukocyte Biology 01-08-2008
Subjects:	Adjuvants, Immunologic - therapeutic use Animals Cytokines - analysis Disease Models, Animal endotoxic Galactosylceramides - therapeutic use Lipopolysaccharides - toxicity MCP‐1 Mice Mice, Inbred C57BL NKT rodent Shock, Septic - chemically induced Shock, Septic - prevention & control Time Factors
Online Access:	Get full text
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