Characteristics of COVID-19 Infection in a Hospitalized Autoimmune Hepatitis Patient

• Published in: Pathogens (Basel) Vol. 11; no. 9; p. 1054
• Main Authors: da Costa, Vanessa Duarte, Wiggers, Wilian Jean, Ivantes, Claudia Alexandra Pontes, da Fonseca, Rodrigo Jardim Monteiro, Dávila, Alberto Martín Rivera, Moreira, Otacilio C, Ferreira, Beatriz Iandra da Silva, de Paula, Vanessa Salete, da Silva, Lucas Lima, Santos, Alanna Calheiros, Villar, Livia Melo
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-09-2022; MDPI
• Subjects: autoimmune hepatitis; Biopsy; Care and treatment; Case Report; Case studies; Chronic active hepatitis; Complications and side effects; Coronaviruses; COVID-19; COVID-19 vaccines; Disease; Drug therapy; Drugs; Dyspnea; Guillain-Barre syndrome; Hematology; Hepatitis; Hospital patients; Hospitalization; Immunosuppression; Immunosuppressive agents; Infections; Laboratories; Liver; Magnetic resonance imaging; Pandemics; Patients; Proteins; Public health; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Thrombocytopenia; Ultrasonic imaging; Viral diseases; Viral infections; Brazil
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens11091054

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a major public health worldwide. Hepatic dysfunction has been seen in patients with COVID-19 and could be related to a viral cytopathic effect, an exacerbated immune reaction, or drug-induced liver damage. Currently, routine modification of immunosuppressive therapy in patients with autoimmune hepatitis (AIH) before and after SARS-CoV-2 infection remains an important topic to be discussed. However, there is little evidence about this thematic to support any recommendation. Here, we described a case report in which the use of an immunosuppressive drug by a patient with diagnosed AIH might have influenced the COVID-19 clinical course with altered laboratory hematological and biochemical parameters during infection.