Gas Chromatographic-Mass Spectrometric Determination of British Anti-Lewisite in Plasma

British anti-Lewisite (BAL) (2,3-dimercapto-1-propanol) is a potential therapeutic compound when used against the effects of cutaneous sulfur mustard, and a method for its determination in plasma has been developed. BAL and the internal standard (IS) ethane dithiol were isolated from plasma samples...

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Bibliographic Details
Published in:	Journal of analytical toxicology Vol. 28; no. 5; pp. 384 - 389
Main Authors:	Byers, C.E., Holloway, E.R., Korte, W.D., Smith, J.R., Clarkson, E.D., Platoff, G.E., Capacio, B.R.
Format:	Journal Article
Language:	English
Published:	Niles, IL Oxford University Press 01-07-2004 Preston
Subjects:	Analysis Animals Biological and medical sciences Chelating Agents - administration & dosage Chelating Agents - analysis Chelating Agents - pharmacokinetics Chemical and industrial products toxicology. Toxic occupational diseases Dimercaprol - administration & dosage Dimercaprol - blood Dimercaprol - pharmacokinetics Disease Models, Animal Gas Chromatography-Mass Spectrometry - methods Gas, fumes General pharmacology Guinea Pigs Injections, Intramuscular Medical sciences Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Swine Toxicology Solid phase extraction Biological fluid Chemical analysis Dimercaprol 2-chlorovinyl dichloroarsine Derivatization Blood Chemical enrichment Blood plasma Chemical warfare agent Guinea pig Sample preparation Acylation Quantitative analysis Coupled method Rodentia Sulfur mustard Gas chromatography Vertebrata Mammalia Mercaptoalcohol Animal Chelating agent Antidote Pharmacokinetics Mass spectrometry Arsenic Organic compounds
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