Mechanism of platelet activating factor-induced vascular leakage in the rat trachea

Platelet activating factor (PAF) is a phospholipid mediator of inflammation and vascular leakage that may be important in the etiology of asthma. We and others have demonstrated that PAF causes vascular leakage in the rat trachea. In the present study, we attempted to determine how PAF mediates this...

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Bibliographic Details
Published in:	Experimental lung research Vol. 18; no. 4; p. 447
Main Authors:	Kirsch, C M, Brokaw, J J, Prow, D M, White, G W
Format:	Journal Article
Language:	English
Published:	England 1992
Subjects:	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - pharmacology Animals Axons - drug effects Biological Transport - physiology Calcium - metabolism Calmodulin - antagonists & inhibitors Capillary Permeability - physiology Capsaicin - pharmacology Cyclooxygenase Inhibitors - pharmacology Female Histamine - physiology Histamine H2 Antagonists - pharmacology Platelet Activating Factor - analogs & derivatives Platelet Activating Factor - antagonists & inhibitors Platelet Activating Factor - physiology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Rats Trachea - blood supply Verapamil - pharmacology
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