Chromosomal Localization of Human Genes Governing the Interferon-Induced Antiviral State

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 72; no. 8; pp. 3129 - 3133
• Main Authors: Chany, C., Vignal, M., Couillin, P., Van Cong, Nguyen, Boue, J., Boue, A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 01-08-1975; National Acad Sciences
• Subjects: Aneuploidy; Antivirals; Cell Line; Cell lines; Cells; Chromosomes; Chromosomes - metabolism; Diploidy; Dose-Response Relationship, Drug; Genes; Hybrid Cells - drug effects; Hybrid Cells - metabolism; Interferons; Interferons - metabolism; Interferons - pharmacology; Karyotyping; L cells; Triploidy; Trisomics; Trisomy; Viral Interference
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.72.8.3129

Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells has been compared. G21 trisomic cells are more sensitive than diploid cells; whereas, on the contrary, triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. These data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studied are involved with interferon synthesis.