Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma

• Published in: The New England journal of medicine Vol. 386; no. 26; pp. 2471 - 2481
• Main Authors: Gállego Pérez-Larraya, Jaime, Garcia-Moure, Marc, Labiano, Sara, Patiño-García, Ana, Dobbs, Jessica, Gonzalez-Huarriz, Marisol, Zalacain, Marta, Marrodan, Lucia, Martinez-Velez, Naiara, Puigdelloses, Montserrat, Laspidea, Virginia, Astigarraga, Itziar, Lopez-Ibor, Blanca, Cruz, Ofelia, Oscoz Lizarbe, Miren, Hervas-Stubbs, Sandra, Alkorta-Aranburu, Gorka, Tamayo, Ibon, Tavira, Beatriz, Hernandez-Alcoceba, Ruben, Jones, Chris, Dharmadhikari, Gitanjali, Ruiz-Moreno, Cristian, Stunnenberg, Henk, Hulleman, Esther, van der Lugt, Jasper, Idoate, Miguel Á., Diez-Valle, Ricardo, Esparragosa Vázquez, Inés, Villalba, Maria, de Andrea, Carlos, Núñez-Córdoba, Jorge M., Ewald, Brett, Robbins, Joan, Fueyo, Juan, Gomez-Manzano, Candelaria, Lang, Frederick F., Tejada, Sonia, Alonso, Marta M.
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 30-06-2022
• Subjects: Adenoviridae; Adolescent; Adverse events; Antitumor activity; Astrocytoma - radiotherapy; Astrocytoma - therapy; Autopsy; Biopsy; Blood tests; Brain cancer; Brain Stem Neoplasms - mortality; Brain Stem Neoplasms - pathology; Brain Stem Neoplasms - radiotherapy; Brain Stem Neoplasms - therapy; Brain Tumor; Brain tumors; Cerebellum; Child; Child, Preschool; Childhood Cancer; Childhood Diseases; Diffuse Intrinsic Pontine Glioma - mortality; Diffuse Intrinsic Pontine Glioma - radiotherapy; Diffuse Intrinsic Pontine Glioma - therapy; Glioma; Glioma - radiotherapy; Glioma - therapy; Hematology; Humans; Immune response; Infectious Disease; Infusions, Intralesional; Lymphocytes T; Magnetic resonance imaging; Medical prognosis; Nausea; Neuroimaging; Neurology; Neurosurgery; Oncology; Oncolysis; Oncolytic Virotherapy - adverse effects; Oncolytic Virotherapy - methods; Oncolytic Viruses; Paresis; Patients; Pediatrics; Pediatrics General; Peripheral blood; Quality of Life; Radiation therapy; Treatments in Oncology; Tumor cells; Tumor Microenvironment; Viral Infections; Viruses; Vomiting
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa2202028

A total of 12 pediatric patients with diffuse intrinsic pontine glioma were treated with a direct infusion of an oncolytic virus, followed by radiotherapy. The tumor size was reduced in 9 patients, and disease was stable over a median follow-up of 18 months in 8 patients.