2-Benzoylpyridine- N(4)-tolyl thiosemicarbazones and their palladium(II) complexes: Cytotoxicity against leukemia cells

The palladium(II) complexes [Pd(2Bz4oT)Cl], [Pd(2Bz4mT)Cl], and [Pd(2Bz4pT)Cl] were prepared with N(4)- ortho- (H2Bz4oT) N(4)- meta- (H2Bz4mT) and N(4)- para- (H2Bz4pT) tolyl-thiosemicarbazones derived from 2-benzoylpyridine. The free thiosemicarbazones proved to be highly cytotoxic against Jurkat,...

Full description

Saved in:

Bibliographic Details
Published in:	Bioorganic & medicinal chemistry Vol. 17; no. 20; pp. 7138 - 7144
Main Authors:	Ferraz, Karina S.O., Ferandes, Lucas, Carrilho, Diego, Pinto, Mauro C.X., Leite, Maria de Fátima, Souza–Fagundes, Elaine M., Speziali, Nivaldo L., Mendes, Isolda C., Beraldo, Heloisa
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 15-10-2009 Elsevier
Subjects:	Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line, Tumor Crystallography, X-Ray Drug Screening Assays, Antitumor General aspects Humans Leukemia Leukemia - pathology Magnetic Resonance Spectroscopy Medical sciences Models, Molecular Palladium - chemistry Palladium(II) complexes Pharmacology. Drug treatments Thiosemicarbazones Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology Thiosemicarbazones Leukemia Palladium(II) complexes Antineoplastic agent Divalent metal Complexes Molecular structure Toxicity Liver Cytotoxicity Pyridine derivatives Hepatocyte T-Lymphocyte Tumor cell Human Promyelocytic leukemia Thiosemicarbazone Palladium II Complexes Organic ligand Transition metal Complexes X ray diffraction In vitro HL60 cell line Position isomer Cell line Platinoid Complexes Toluene derivatives Crystalline structure
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!