Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling

Astragaloside IV (AS-IV), the major active triterpenoid in Radix Astragali, has shown anti-tumorigenic properties in certain cancers; however, its role in breast cancer remains unclear. The present study investigated the effects of AS-IV on breast cancer in vitro and in vivo and examined the underly...

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Bibliographic Details
Published in:	International immunopharmacology Vol. 42; pp. 195 - 202
Main Authors:	Jiang, Ke, Lu, Qing, Li, Qiong, Ji, Yajie, Chen, Weili, Xue, Xiaohong
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-01-2017 Elsevier BV
Subjects:	Animals Anticancer properties Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis - drug effects Astragaloside IV Breast cancer Breast cancer cells Breast Neoplasms - drug therapy Breast Neoplasms - pathology Cancer Cell growth Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Drugs, Chinese Herbal Ectopic expression Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases Female Folk medicine Guanine Guanine nucleotide exchange factor Guanosine triphosphatases Humans In vitro methods and tests In vivo methods and tests Invasiveness JNK protein Lungs MAP kinase Metastases Metastasis Mice Mice, Nude Protein kinase Proto-Oncogene Proteins c-vav - genetics Proto-Oncogene Proteins c-vav - metabolism rac1 GTP-Binding Protein - metabolism Rac1 protein Rac1/MAPK signaling RNA, Small Interfering - genetics Saponins - pharmacology Signal Transduction - drug effects Triterpenes - pharmacology Tumor Burden - drug effects Vav3 Western blotting Xenograft Model Antitumor Assays Vav3 Astragaloside IV Breast cancer cells Rac1/MAPK signaling
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