Targeting the cryptic sites: NMR-based strategy to improve protein druggability by controlling the conformational equilibrium

Cryptic ligand binding sites, which are not evident in the unligated structures, are beneficial in tackling with difficult but attractive drug targets, such as protein-protein interactions (PPIs). However, cryptic sites have thus far not been rationally pursued in the early stages of drug developmen...

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Bibliographic Details

Published in:	Science advances Vol. 6; no. 40
Main Authors:	Mizukoshi, Yumiko, Takeuchi, Koh, Tokunaga, Yuji, Matsuo, Hitomi, Imai, Misaki, Fujisaki, Miwa, Kamoshida, Hajime, Takizawa, Takeshi, Hanzawa, Hiroyuki, Shimada, Ichio
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 01-09-2020
Subjects:	Research Methods SciAdv r-articles Structural Biology
Online Access:	Get full text
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