Genotoxic and antigenotoxic effects of catechin and tannins from the bark of Hamamelis virginiana L. in metabolically competent, human hepatoma cells (Hep G2) using single cell gel electrophoresis

The genotoxic and antigenotoxic activities of catechin, hamamelitannin and two proanthocyanidin fractions prepared from the bark of Hamamelis virginiana L. were investigated in a human derived, metabolically competent hepatoma cell line (Hep G2) using single cell gel electrophoresis (SCGE) for the d...

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Published in:	Phytochemistry (Oxford) Vol. 63; no. 2; pp. 199 - 207
Main Authors:	Dauer, Andreas, Hensel, Andreas, Lhoste, Evelyne, Knasmüller, Siegfried, Mersch-Sundermann, Volker
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 01-05-2003 Elsevier
Subjects:	Anthocyanins - isolation & purification Anthocyanins - pharmacology Anthocyanins - toxicity Antigenotoxicity Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - toxicity Benzo(a)pyrene - metabolism Benzo(a)pyrene - toxicity Biological and medical sciences Carcinoma, Hepatocellular - genetics Catechin Catechin - isolation & purification Catechin - pharmacology Catechin - toxicity Chemical constitution Cytochrome P-450 CYP1A1 - metabolism DNA Damage Electrophoresis, Agar Gel - methods Fundamental and applied biological sciences. Psychology Gallic Acid - analogs & derivatives Gallic Acid - isolation & purification Gallic Acid - pharmacology Gallic Acid - toxicity General pharmacology Genotoxicity Hamamelidaceae Hamamelis - chemistry Hamamelis virginiana Hamamelis virginiana L Hep G2 cells Hexoses - isolation & purification Hexoses - pharmacology Hexoses - toxicity Humans Life Sciences Liver Neoplasms - genetics Medical sciences Mutagens - isolation & purification Mutagens - pharmacology Mutagens - toxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plant physiology and development Proanthocyanidins SCGE assay Tannins Tumor Cells, Cultured Hep G2 cells Hamamelis virginiana L Catechin Tannins SCGE assay Genotoxicity Hamamelidaceae Antigenotoxicity Proanthocyanidins Human Bioassay Benzopyrene Essential oil plant Toxicity Bark Biological activity Cell line Hepatocyte Dicotyledones Angiospermae Plant origin Isolation Spermatophyta Vegetal tannin
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