Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties

Stachybotrin C and parvisporin, novel neuritogenic compounds. I. Taxonomy, isolation, physico-chemical and biological properties

Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin d...

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Bibliographic Details
Published in:Journal of antibiotics Vol. 50; no. 8; p. 635
Main Authors: Nozawa, Y, Yamamoto, K, Ito, M, Sakai, N, Mizoue, K, Mizobe, F, Hanada, K
Format: Journal Article
Language:English
Published: Japan 1997
Subjects:
Animals
Benzaldehydes - chemistry
Benzaldehydes - isolation & purification
Benzaldehydes - pharmacology
Benzopyrans - chemistry
Benzopyrans - isolation & purification
Benzopyrans - pharmacology
Cell Survival - drug effects
Cells, Cultured
Cerebral Cortex - drug effects
Fatty Alcohols - chemistry
Fatty Alcohols - isolation & purification
Fatty Alcohols - pharmacology
Fermentation
Indoles - chemistry
Indoles - isolation & purification
Indoles - pharmacology
Neurons - drug effects
Rats
Rats, Wistar
Stachybotrys
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Summary:Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin demonstrated only weak neuritogenic activity.
ISSN:0021-8820
DOI:10.7164/antibiotics.50.635