Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB‐EGF and TGF‐α

The mechanisms by which mechanical forces promote fetal lung development are not fully understood. Here, we investigated differentiation of fetal type II epithelial cells via the epidermal growth factor receptor (EGFR) in response to mechanical strain. First, we showed that incubation of embryonic d...

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Bibliographic Details
Published in:	The Journal of physiology Vol. 587; no. 8; pp. 1739 - 1753
Main Authors:	Wang, Yulian, Maciejewski, Benjamin S., Soto‐Reyes, Dariana, Lee, Hyeon‐Soo, Warburton, David, Sanchez‐Esteban, Juan
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 15-04-2009 Blackwell Science Inc
Subjects:	Animals Blotting, Northern Cell Differentiation - drug effects Cell Differentiation - physiology Cell Separation Electroporation Epithelial Cells - drug effects Epithelial Cells - physiology Female Fibroblasts - physiology Gestational Age Heparin-binding EGF-like Growth Factor Intercellular Signaling Peptides and Proteins - metabolism Lung - embryology Lung - physiology Microscopy, Fluorescence Physical Stimulation Pregnancy Pulmonary Stretch Receptors - drug effects Pulmonary Stretch Receptors - physiology Rats Rats, Sprague-Dawley Respiratory Reverse Transcriptase Polymerase Chain Reaction Transfection Transforming Growth Factor alpha - metabolism
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