NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans

Previous brain imaging studies with [11C]raclopride have suggested that the psychotogenic effects of the noncompetitive N‐methyl‐D‐aspartate antagonist ketamine in humans might be mediated by increased dopamine (DA) release and increased stimulation of DA D2 receptors in the striatum. The goal of th...

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Bibliographic Details
Published in:	Synapse (New York, N.Y.) Vol. 43; no. 1; pp. 19 - 29
Main Authors:	Kegeles, Lawrence S., Martinez, Diana, Kochan, Lisa D., Hwang, Dah-Ren, Huang, Yiyun, Mawlawi, Osama, Suckow, R. F., Van Heertum, Ronald L., Laruelle, Marc
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 01-01-2002
Subjects:	[11C]raclopride Adult Antipsychotic Agents - pharmacokinetics Behavior - drug effects Behavior - physiology Binding, Competitive - drug effects Binding, Competitive - physiology Cerebellum - diagnostic imaging Cerebellum - drug effects dopamine Dopamine - metabolism Dopamine - secretion Drug Interactions - physiology Excitatory Amino Acid Antagonists - adverse effects Excitatory Amino Acid Antagonists - blood Excitatory Amino Acid Antagonists - pharmacology Female glutamate Humans ketamine Ketamine - adverse effects Ketamine - blood Ketamine - pharmacokinetics Male Middle Aged Neostriatum - diagnostic imaging Neostriatum - drug effects Neurons - diagnostic imaging Neurons - drug effects Nucleus Accumbens - diagnostic imaging Nucleus Accumbens - drug effects PET raclopride Raclopride - pharmacokinetics Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism schizophrenia Tomography, Emission-Computed
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